REM-associated sleep apnoea: prevalence and clinical significance in the HypnoLaus cohort.

Details

Serval ID
serval:BIB_4E7A00C5AC6B
Type
Article: article from journal or magazin.
Collection
Publications
Title
REM-associated sleep apnoea: prevalence and clinical significance in the HypnoLaus cohort.
Journal
The European respiratory journal
Author(s)
Acosta-Castro P., Hirotsu C., Marti-Soler H., Marques-Vidal P., Tobback N., Andries D., Waeber G., Preisig M., Vollenweider P., Haba-Rubio J., Heinzer R.
ISSN
1399-3003 (Electronic)
ISSN-L
0903-1936
Publication state
Published
Issued date
08/2018
Peer-reviewed
Oui
Volume
52
Number
2
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
This study determined the prevalence of rapid eye movement (REM) related sleep-disordered breathing (REM-SDB) in the general population and investigated the associations of REM-SDB with hypertension, metabolic syndrome, diabetes and depression.Home polysomnography (PSG) recordings (n=2074) from the population-based HypnoLaus Sleep Cohort (48.3% men, 57±11 years old) were analysed. The apnoea-hypopnoea index was measured during REM and non-REM sleep (as REM-AHI and NREM-AHI, respectively). Regression models were used to explore the associations between REM-SDB and hypertension, diabetes, metabolic syndrome and depression in the entire cohort and in subgroups with NREM-AHI <10 events·h <sup>-1</sup> and total AHI <10 events·h <sup>-1</sup> The prevalence of REM-AHI ≥20 events·h <sup>-1</sup> was 40.8% in the entire cohort. An association between increasing REM-AHI and metabolic syndrome was found in the entire cohort and in both the NREM-AHI and AHI subgroups (p-trend=0.014, <0.0001 and 0.015, respectively). An association was also found between REM-AHI ≥20 events·h <sup>-1</sup> and diabetes in both the NREM-AHI <10 events·h <sup>-1</sup> (odds ratio (OR) 3.12 (95% CI 1.35-7.20)) and AHI <10 events·h <sup>-1</sup> (OR 2.92 (95% CI 1.12-7.63)) subgroups. Systolic and diastolic blood pressure were positively associated with REM-AHI ≥20 events·h <sup>-1</sup> REM-SDB is highly prevalent in our middle-to-older age sample and is independently associated with metabolic syndrome and diabetes. These findings suggest that an increase in REM-AHI could be clinically relevant.
Keywords
Adult, Aged, Aged, 80 and over, Blood Pressure, Cohort Studies, Depression/epidemiology, Diabetes Mellitus/epidemiology, Female, Humans, Hypertension/epidemiology, Linear Models, Logistic Models, Male, Metabolic Syndrome/epidemiology, Middle Aged, Polysomnography, Prevalence, Severity of Illness Index, Sleep Apnea Syndromes/diagnosis, Sleep Apnea Syndromes/epidemiology, Sleep, REM, Switzerland/epidemiology
Pubmed
Web of science
Create date
10/07/2018 14:50
Last modification date
20/08/2019 15:04
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