Multimodal imaging of the dynamic brain tumor microenvironment during glioblastoma progression and in response to treatment.

Details

Serval ID
serval:BIB_4E776CBAF3C1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Multimodal imaging of the dynamic brain tumor microenvironment during glioblastoma progression and in response to treatment.
Journal
iScience
Author(s)
Zomer A., Croci D., Kowal J., van Gurp L., Joyce J.A.
ISSN
2589-0042 (Electronic)
ISSN-L
2589-0042
Publication state
Published
Issued date
15/07/2022
Peer-reviewed
Oui
Volume
25
Number
7
Pages
104570
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Tumors evolve in a dynamic communication with their native tissue environment and recruited immune cells. The diverse components of the tumor microenvironment (TME) can critically regulate tumor progression and therapeutic response. In turn, anticancer treatments may alter the composition and functions of the TME. To investigate this continuous dialog in the context of primary brain cancers, we developed a multimodal longitudinal imaging strategy. We combined macroscopical magnetic resonance imaging with subcellular resolution two-photon intravital microscopy, and leveraged the power of single-cell analysis tools to gain insights into the ongoing interactions between different components of the TME and cancer cells. Our experiments revealed that the migratory behavior of tumor-associated macrophages is different in genetically distinct glioblastomas, and in response to macrophage-targeted therapy. These results underscore the importance of studying cancer longitudinally in an in vivo setting, to reveal complex and dynamic alterations in the TME during disease progression and therapeutic intervention.
Keywords
Cancer, Medical imaging, Microenvironment, Physics magnetic resonance imaging
Pubmed
Open Access
Yes
Create date
13/07/2022 12:44
Last modification date
15/07/2022 6:36
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