Circulating insulin-like growth factor-I in pregnancy and maternal risk of breast cancer.

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Version: Final published version
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Serval ID
serval:BIB_4E457A3954C1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Circulating insulin-like growth factor-I in pregnancy and maternal risk of breast cancer.
Journal
Cancer Epidemiology, Biomarkers and Prevention
Author(s)
Toriola Adetunji T., Lundin Eva, Schock Helena, Grankvist Kjell, Pukkala Eero, Chen Tianhui, Zeleniuch-Jacquotte Anne, Toniolo Paolo, Lehtinen Matti, Surcel Helja-Marja, Lukanova Annekatrin
ISSN
1538-7755 (Electronic)
ISSN-L
1055-9965
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
20
Number
8
Pages
1798-1801
Language
english
Abstract
BACKGROUND: Elevated serum concentrations of insulin-like growth factor (IGF)-1 have been associated with increased risk of breast cancer. Previously, we reported a similar association in samples obtained during pregnancy. The current study was conducted to further characterize the association of IGF-1 during pregnancy with maternal breast cancer risk. METHODS: A case-control study was nested within the Finnish Maternity Cohort. The study was limited to primiparous women less than 40 years of age, who donated blood samples during early (median, 12 weeks) pregnancy and delivered a single child at term. Seven hundred and nineteen women with invasive breast cancer were eligible. Two controls (n = 1,434) were matched to each case on age and date at blood donation. Serum IGF-1 concentration was measured using an Immulite 2000 analyzer. Conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI).RESULTS: No significant associations were observed between serum IGF-1 concentrations and breast cancer risk in both the overall analysis (OR 1.08 (95% CI 0.80-1.47) and in analyses stratified by histological subtype, lag-time to cancer diagnosis, age at pregnancy or age at diagnosis.CONCLUSIONS: There was no association between IGF-1 and maternal breast cancer risk during early pregnancy in this large nested case-control study.Impact:Serum IGF-1 concentrations during early pregnancy may not be related to maternal risk of breast cancer.
Pubmed
Web of science
Create date
23/06/2011 8:34
Last modification date
20/08/2019 15:03
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