Clinical potential of minocycline for neurodegenerative disorders.

Details

Serval ID
serval:BIB_4E3EBA137A3F
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Clinical potential of minocycline for neurodegenerative disorders.
Journal
Neurobiology of Disease
Author(s)
Blum D., Chtarto A., Tenenbaum L., Brotchi J., Levivier M.
ISSN
0969-9961 (Print)
ISSN-L
0969-9961
Publication state
Published
Issued date
2004
Peer-reviewed
Oui
Volume
17
Number
3
Pages
359-366
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Minocycline, an antibiotic of the tetracycline family, has been shown to display neurorestorative or neuroprotective properties in various models of neurodegenerative diseases. In particular, it has been shown to delay motor alterations, inflammation and apoptosis in models of Huntington's disease, amyotrophic lateral sclerosis and Parkinson's disease. Despite controversies about its efficacy, the relative safety and tolerability of minocycline have led to the launching of various clinical trials. The present review summarizes the available data supporting the clinical testing of minocycline for these neurodegenerative disorders. In addition, we extend our discussion to the potential applications of minocycline for combining this treatment with cellular and molecular therapy.
Keywords
Animals, Apoptosis, Humans, Huntington Disease/drug therapy, Inflammation, Minocycline/therapeutic use, Motor Neuron Disease/drug therapy, Neurodegenerative Diseases/drug therapy, Neurodegenerative Diseases/pathology, Neuroprotective Agents/therapeutic use, Parkinson Disease/drug therapy
Pubmed
Web of science
Create date
20/01/2008 17:35
Last modification date
20/08/2019 14:03
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