Association of RANTES G-403A gene polymorphism with increased risk of coronary arteriosclerosis

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Serval ID
serval:BIB_4E13E0201A5D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Association of RANTES G-403A gene polymorphism with increased risk of coronary arteriosclerosis
Journal
European Heart Journal
Author(s)
Simeoni  E., Winkelmann  B. R., Hoffmann  M. M., Fleury  S., Ruiz  J., Kappenberger  L., Marz  W., Vassalli  G.
ISSN
0195-668X (Print)
Publication state
Published
Issued date
08/2004
Volume
25
Number
16
Pages
1438-46
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug
Abstract
AIMS: Polymorphisms in the RANTES (G-403A), monocyte chemoattractant protein-1 (MCP-1; A-2518G), stromal cell-derived factor-1beta (SDF-1beta; G801A), and C-C chemokine receptor-5 (CCR5; Delta32) genes have been associated with functional effects. These chemokines have been implicated in leucocyte recruitment to arterial lesions. In a case-control study, we explored relations between these polymorphisms and coronary artery disease (CAD), with respect to angiographic abnormalities and acute coronary syndromes (ACS). METHODS AND RESULTS: The LUdwigshafen Risk and Cardiovascular health (LURIC) cohort was genotyped by RFLP-PCR. Based on coronary angiography, individuals were sub-divided into CAD cases (n = 2694) and controls (n = 530). RANTES-403 genotype frequencies were significantly different in cases and controls (chi2 = 4.17, p = 0.041), as were A allele carrier frequencies (36.01% vs. 30.19%, OR = 1.30 [95%-CI = 1.06-1.60], p = 0.010). By multivariate analysis, RANTES A-403 retained significant association with CAD (chi2 = 8.40, p = 0.0038). RANTES A-403 was associated with increased ACS prevalence (OR = 1.36 [95%-CI = 1.08-1.71], p = 0.0073). MCP-1 G-2518, SDF-1beta A801, and CCR5 Delta32 were not associated with CAD. CONCLUSIONS: RANTES A-403 was associated with CAD independently from conventional risk factors and CRP or fibrinogen as inflammatory biomarkers. The association was enhanced in smokers and ACS, conditions where platelet activation and inflammation predominate. RANTES A-403 may increase genetic susceptibility to CAD.
Keywords
Case-Control Studies Coronary Arteriosclerosis/*genetics Female Genetic Predisposition to Disease Genotype Humans Male Middle Aged Polymorphism, Genetic/*genetics RANTES/*genetics Risk Factors
Pubmed
Web of science
Open Access
Yes
Create date
15/02/2008 11:29
Last modification date
25/09/2019 6:09
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