Prevalence and Significance of Hypermetabolic Lymph Nodes Detected by 2-[18F]FDG PET/CT after COVID-19 Vaccination: A Systematic Review and a Meta-Analysis.

Details

Serval ID
serval:BIB_4E002753554C
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Prevalence and Significance of Hypermetabolic Lymph Nodes Detected by 2-[18F]FDG PET/CT after COVID-19 Vaccination: A Systematic Review and a Meta-Analysis.
Journal
Pharmaceuticals
Author(s)
Treglia G., Cuzzocrea M., Giovanella L., Elzi L., Muoio B.
ISSN
1424-8247 (Print)
ISSN-L
1424-8247
Publication state
Published
Issued date
03/08/2021
Peer-reviewed
Oui
Volume
14
Number
8
Pages
762
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Recently, several articles reported incidental findings at 2-[ <sup>18</sup> F]FDG PET/CT in patients who have received COVID-19 vaccinations, including hypermetabolic axillary lymph nodes (HALNs) ipsilateral to the COVID-19 vaccine injection site which may cause diagnostic dilemmas. The aim of our work was to calculate the prevalence of this finding. A comprehensive computer literature search of PubMed/MEDLINE, Embase, and Cochrane library databases was performed to identify recently published articles that investigated the prevalence of HALNs detected by 2-[ <sup>18</sup> F]FDG PET/CT after COVID-19 vaccination. Pooled prevalence of this finding was calculated through a meta-analytic approach. Nine recently published articles including 2354 patients undergoing 2-[ <sup>18</sup> F]FDG PET/CT after recent COVID-19 vaccination have been included in the systematic review. Overall, HALNs ipsilateral to the vaccine injection site were frequent findings mainly due to vaccine-related immune response in most of the cases. The pooled prevalence of HALNs after COVID-19 vaccination was 37% (95% confidence interval: 27-47%) but with significant heterogeneity among the included studies. Physicians must be aware and recognize the significant frequency of HALNs at 2-[ <sup>18</sup> F]FDG PET/CT related to immune response to vaccine injection. Larger studies are needed to confirm the findings of this systematic review and meta-analysis.
Keywords
COVID-19, FDG, PET, inflammation, lymph nodes, meta-analysis, systematic review, vaccine
Pubmed
Web of science
Open Access
Yes
Create date
10/09/2021 17:53
Last modification date
16/12/2021 6:33
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