Disseminated Rhizopus microsporus infection cured by salvage allogeneic hematopoietic stem cell transplantation, antifungal combination therapy, and surgical resection.

Details

Serval ID
serval:BIB_4DF6A9D3D151
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Disseminated Rhizopus microsporus infection cured by salvage allogeneic hematopoietic stem cell transplantation, antifungal combination therapy, and surgical resection.
Journal
Transplant Infectious Disease
Author(s)
Lebeau O., Van Delden C., Garbino J., Robert J., Lamoth F., Passweg J., Chalandon Y.
ISSN
1399-3062[electronic], 1398-2273[linking]
Publication state
Published
Issued date
2010
Volume
12
Number
3
Pages
269-272
Language
english
Abstract
O. Lebeau, C. Van Delden, J. Garbino, J. Robert, F. Lamoth, J. Passweg, Y. Chalandon. Disseminated Rhizopus microsporus infection cured by salvage allogeneic hematopoietic stem cell transplantation, antifungal combination therapy, and surgical resection. Transpl Infect Dis 2010. All rights reserved Abstract: Invasive Zygomycetes infection complicating prolonged neutropenia is associated with high mortality in the absence of immune recovery. We report a patient who developed disseminated zygomycosis due to Rhizopus microsporus during induction chemotherapy for acute myeloid leukemia. Rescue allogeneic hematopoietic stem cell transplantation (allo-HSCT) was performed as her only chance of cure of this infection and to treat refractory leukemia. Posaconazole combined with liposomal amphotericin B contained the zygomycosis during prolonged neutropenia due to allo-HSCT followed by intense immunosuppression for grade IV acute graft-versus-host disease. Surgical removal of all infected sites after immune recovery, with prolonged posaconazole treatment, ultimately cured the infection. New combination antifungal therapies might sufficiently control disseminated zygomycosis to allow allo-HSCT to be performed, assuring life-saving immune recovery. Surgery appears to be necessary for definite cure of these infections.
Keywords
Hematopoietic Stem Cell Transplantation, Zygomycetes, Zygomycosis, Rhizopus Microsporus, Liposomal Amphotericin B, Posaconazole, Digestive Graft-Versus-Host Disease, Surgical Resection
Pubmed
Web of science
Create date
23/06/2010 10:11
Last modification date
20/08/2019 15:03
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