Accelerated telomere shortening in hematological lineages is limited to the first year following stem cell transplantation.

Details

Serval ID
serval:BIB_4DDB575A7A90
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Accelerated telomere shortening in hematological lineages is limited to the first year following stem cell transplantation.
Journal
Blood
Author(s)
Rufer N., Brümmendorf T.H., Chapuis B., Helg C., Lansdorp P.M., Roosnek E.
ISSN
0006-4971
Publication state
Published
Issued date
2001
Peer-reviewed
Oui
Volume
97
Number
2
Pages
575-577
Language
english
Abstract
Using quantitative fluorescence in situ hybridization and flow cytometry, the telomere length of telomere repeat sequences after stem cell transplantation (SCT) were measured. The study included the telomeres of peripheral blood monocytes that should reflect the length of telomeres in stem cells and the telomeres of T lymphocytes that could shorten as a result of peripheral expansion. The loss of telomeres in monocytes and in memory T cells, although accelerated initially, became comparable to the loss of telomeres in healthy controls from the second year after transplantation. In addition, the telomere length in the naive T cells that were produced by the thymus was comparable to the telomere length in the naive T cells of the donor. Compared to the total length of telomeres available, the loss of telomere repeats in leukocytes after SCT resembles the accelerated shortening seen in early childhood and remains, therefore, relatively insignificant.
Keywords
Adult, CD4-Positive T-Lymphocytes/cytology, CD4-Positive T-Lymphocytes/ultrastructure, Cell Culture Techniques, Cell Division/genetics, Follow-Up Studies, Hematopoiesis/genetics, Hematopoietic Stem Cell Transplantation/adverse effects, Humans, In Situ Hybridization, Fluorescence, Leukemia/blood, Leukemia/therapy, Monocytes/cytology, Monocytes/ultrastructure, T-Lymphocytes/cytology, T-Lymphocytes/ultrastructure, Telomere/physiology, Time Factors
Pubmed
Web of science
Open Access
Yes
Create date
13/10/2009 8:15
Last modification date
20/08/2019 14:03
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