Modes of action and diagnostic value of miRNAs in sepsis.

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State: Public
Version: author
License: CC BY 4.0
Serval ID
serval:BIB_4DC5945A7D32
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Modes of action and diagnostic value of miRNAs in sepsis.
Journal
Frontiers in immunology
Author(s)
Antonakos N. (co-first), Gilbert C. (co-first), Théroude C., Schrijver I.T., Roger T.
ISSN
1664-3224 (Electronic)
ISSN-L
1664-3224
Publication state
Published
Issued date
2022
Peer-reviewed
Oui
Volume
13
Pages
951798
Language
english
Notes
Publication types: Journal Article ; Review ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Sepsis is a clinical syndrome defined as a dysregulated host response to infection resulting in life-threatening organ dysfunction. Sepsis is a major public health concern associated with one in five deaths worldwide. Sepsis is characterized by unbalanced inflammation and profound and sustained immunosuppression, increasing patient susceptibility to secondary infections and mortality. microRNAs (miRNAs) play a central role in the control of many biological processes, and deregulation of their expression has been linked to the development of oncological, cardiovascular, neurodegenerative and metabolic diseases. In this review, we discuss the role of miRNAs in sepsis pathophysiology. Overall, miRNAs are seen as promising biomarkers, and it has been proposed to develop miRNA-based therapies for sepsis. Yet, the picture is not so straightforward because of the versatile and dynamic features of miRNAs. Clearly, more research is needed to clarify the expression and role of miRNAs in sepsis, and to promote the use of miRNAs for sepsis management.
Keywords
Biomarkers/metabolism, Humans, Immune Tolerance, Inflammation, MicroRNAs/metabolism, Sepsis/diagnosis, Sepsis/drug therapy, Sepsis/genetics, biomarkers, critically ill, infection, innate immunity, miRNA, sepsis
Pubmed
Web of science
Open Access
Yes
Funding(s)
SNF/Projects/310030_207418 EC/H2020/676129 OTHER//Fondation Carigest-Promex Stiftung für die Forschung OTHER//Fondation de Recherche en Biochimie OTHER//Porphyrogenis Foundation OTHER//Société Académique Vaudoise
Create date
30/08/2022 9:46
Last modification date
02/09/2022 6:39
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