Distinct and shared gene expression for human innate versus adaptive helper lymphoid cells.

Details

Serval ID
serval:BIB_4DA23DC9CF93
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Distinct and shared gene expression for human innate versus adaptive helper lymphoid cells.
Journal
Journal of leukocyte biology
Author(s)
Ercolano G., Wyss T., Salomé B., Romero P., Trabanelli S., Jandus C.
ISSN
1938-3673 (Electronic)
ISSN-L
0741-5400
Publication state
Published
Issued date
08/2020
Peer-reviewed
Oui
Volume
108
Number
2
Pages
723-737
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Innate lymphoid cells (ILCs) are the latest identified innate immune cell family. Given their similarity in transcription factor expression and cytokine secretion profiles, ILCs have been considered as the innate phenocopy of CD4 Th cells. Here, we explored the transcriptome of circulating human ILC subsets as opposed to CD4 Th cell subsets. We describe transcriptomic differences between total ILCs and total CD4 Th cells, as well as between paired innate and adaptive cell subsets (ILC1 vs. Th1; ILC2 vs. Th2; and ILC3 vs. Th17 cells). In particular, we observed differences in expression of genes involved in cell trafficking such as CCR1, CCR6 and CXCR3, innate activation and inhibitory functions, including CD119, 2B4, TIGIT, and CTLA-4, and neuropeptide receptors, such as VIPR2. Moreover, we report for the first time on distinct expression of long noncoding RNAs (lncRNAs) in innate vs. adaptive cells, arguing for a potential role of lncRNA in shaping human ILC biology. Altogether, our results point for unique, rather than redundant gene organization in ILCs compared to CD4 Th cells, in regard to kinetics, fine-tuning and spatial organization of the immune response.
Keywords
CD4 T helper cells, ILCs, RNAseq, human, lncRNAs
Pubmed
Web of science
Open Access
Yes
Create date
06/02/2020 17:17
Last modification date
02/09/2020 5:22
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