Procalcitonin kinetics in the prognosis of severe community-acquired pneumonia

Details

Serval ID
serval:BIB_4D6E8ECBD68E
Type
Article: article from journal or magazin.
Collection
Publications
Title
Procalcitonin kinetics in the prognosis of severe community-acquired pneumonia
Journal
Intensive Care Med
Author(s)
Boussekey N., Leroy O., Alfandari S., Devos P., Georges H., Guery B.
ISSN
0342-4642 (Print)
ISSN-L
0342-4642
Publication state
Published
Issued date
03/2006
Volume
32
Number
3
Pages
469-72
Language
english
Notes
Boussekey, Nicolas
Leroy, Olivier
Alfandari, Serge
Devos, Patrick
Georges, Hugues
Guery, Benoit
eng
Intensive Care Med. 2006 Mar;32(3):469-72. doi: 10.1007/s00134-005-0047-8. Epub 2006 Feb 14.
Abstract
OBJECTIVES: Procalcitonin (PCT) kinetics is a good prognosis marker in infectious diseases, but few studies of community-acquired pneumonia (CAP) have been performed in intensive care units (ICU). We analyzed the relationship between PCT kinetics and outcome in ICU patients with severe CAP. DESIGN AND SETTING: Prospective observational study in a 16-bed university hospital ICU. PATIENTS: 100 critically ill patients with community-acquired pneumonia. MEASUREMENTS AND RESULTS: Median PCT was 5.2 ng/ml on day 1 and 2.9 ng/ml on day 3. It increased from day 1 to day 3 in nonsurvivors but decreased in survivors. In multivariate analysis four variables were associated with death: invasive ventilation (odds ratio 10-), multilobar involvement (5.6-), LOD score (6.9-), and PCT increase from day 1 to day 3 (4.5-). In intubated patients with a PCT level below 0.95 ng/ml on day 3 the survival rate was 95%. CONCLUSION: Increased PCT from day 1 to day 3 in severe CAP is a poor prognosis factor. A PCT level less than 0.95 ng/ml on day 3 in intubated patients is associated with a favorable outcome.
Keywords
Aged, Calcitonin/analysis/*pharmacokinetics, Calcitonin Gene-Related Peptide, *Community-Acquired Infections/diagnosis/physiopathology, France, Hospitals, University, Humans, Intensive Care Units, Middle Aged, Pneumonia/*diagnosis, Prospective Studies, Protein Precursors/analysis/*pharmacokinetics, Severity of Illness Index
Pubmed
Create date
29/04/2021 10:59
Last modification date
30/04/2021 6:38
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