Procalcitonin kinetics in the prognosis of severe community-acquired pneumonia.

Details

Serval ID
serval:BIB_4D6E8ECBD68E
Type
Article: article from journal or magazin.
Collection
Publications
Title
Procalcitonin kinetics in the prognosis of severe community-acquired pneumonia.
Journal
Intensive care medicine
Author(s)
Boussekey N., Leroy O., Alfandari S., Devos P., Georges H., Guery B.
ISSN
0342-4642 (Print)
ISSN-L
0342-4642
Publication state
Published
Issued date
03/2006
Peer-reviewed
Oui
Volume
32
Number
3
Pages
469-472
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Procalcitonin (PCT) kinetics is a good prognosis marker in infectious diseases, but few studies of community-acquired pneumonia (CAP) have been performed in intensive care units (ICU). We analyzed the relationship between PCT kinetics and outcome in ICU patients with severe CAP.
Prospective observational study in a 16-bed university hospital ICU.
100 critically ill patients with community-acquired pneumonia.
Median PCT was 5.2 ng/ml on day 1 and 2.9 ng/ml on day 3. It increased from day 1 to day 3 in nonsurvivors but decreased in survivors. In multivariate analysis four variables were associated with death: invasive ventilation (odds ratio 10-), multilobar involvement (5.6-), LOD score (6.9-), and PCT increase from day 1 to day 3 (4.5-). In intubated patients with a PCT level below 0.95 ng/ml on day 3 the survival rate was 95%.
Increased PCT from day 1 to day 3 in severe CAP is a poor prognosis factor. A PCT level less than 0.95 ng/ml on day 3 in intubated patients is associated with a favorable outcome.
Keywords
Aged, Calcitonin/analysis, Calcitonin/pharmacokinetics, Calcitonin Gene-Related Peptide, Community-Acquired Infections/diagnosis, Community-Acquired Infections/physiopathology, France, Hospitals, University, Humans, Intensive Care Units, Middle Aged, Pneumonia/diagnosis, Prospective Studies, Protein Precursors/analysis, Protein Precursors/pharmacokinetics, Severity of Illness Index
Pubmed
Web of science
Create date
29/04/2021 9:59
Last modification date
17/07/2023 14:03
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