This paper aims to explain how different supply chain security initiatives and programs affect different supply chain partners and their operational efficiency. Three in-depth cases-a global consumer goods company, a carrier, and a port operator-were studied through multiple interviews to understand how the five supply chain security initiatives affected their operational efficiency. The case organizations, security programs, and aspects of operational efficiency were triangulated in the case analysis to derive managerial and practical implications. The findings indicate that over the short term, implementing the supply chain security initiatives increases freight fees and overhead costs due to the needed technology and IT investments, but the case organizations also benefit from information transparency, better partnering, and above all means of achieving resilient and efficient operational supply chains. Other benefits include reductions in the following supply chain problem areas: theft, smuggling, counterfeit, and loss and damage. Some supply chain partners see that the changes also generate new business opportunities.