Urinary Cadmium Excretion Is Associated With Increased Synthesis of Cortico- and Sex Steroids in a Population Study.

Details

Serval ID
serval:BIB_4D1CB298A7F9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Urinary Cadmium Excretion Is Associated With Increased Synthesis of Cortico- and Sex Steroids in a Population Study.
Journal
The Journal of clinical endocrinology and metabolism
Author(s)
Bochud M., Jenny-Burri J., Pruijm M., Ponte B., Guessous I., Ehret G., Petrovic D., Dudler V., Haldimann M., Escher G., Dick B., Mohaupt M., Paccaud F., Burnier M., Péchère-Bertschi A., Martin P.Y., Vogt B., Ackermann D.
ISSN
1945-7197 (Electronic)
ISSN-L
0021-972X
Publication state
Published
Issued date
01/02/2018
Peer-reviewed
Oui
Volume
103
Number
2
Pages
748-758
Language
english
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Urinary cadmium (Cd) excretion is associated with cancer and cardiovascular morbidity. A potential mechanism could be disturbance of steroidogenesis in gonads and adrenal glands.
We tested whether urinary excretion of Cd is correlated with that of cortico- and sex steroid metabolites in the general adult population.
The Swiss Kidney Project on Genes in Hypertension is a multicentric, family-based population study.
Urinary excretions of steroid hormone metabolites and Cd were measured with separate day and night collections. Associations were analyzed by mixed linear models.
Urinary Cd and testosterone excretions in men were significantly correlated (respective day and night β values [standard error (SE)], 1.378 [0.242], P < 0.0005; and 1.440 [0.333], P < 0.0005), but not in women [0.333(0.257), P = 0.2; and 0.674 (0.361), P = 0.06]. Urinary Cd and cortisol excretions were positively associated in both sexes [day: β = 0.475 (SE, 0.157), P = 0.0025, and 0.877 (SE, 0.194), P < 0.0005, respectively; night: β = 0.875 (SE, 0.253), P < 0.0005 and 1.183 (SE, 0.277), P = 0.00002, respectively]. Cd excretion was correlated with mineralocorticoid metabolites excretion, except tetrahydroaldosterone, in both sexes (P < 0.01). There was an independent effect of Cd on sex hormone and corticosteroid synthesis and an interdependent effect on gluco- and mineralcorticoid production.
Our findings provide evidence for a global stimulating effect on steroid synthesis already at low-dose Cd exposure. These findings might explain the association of Cd with diseases such as steroid-sensitive cancers or metabolic disorders.
Keywords
Adrenal Cortex Hormones/metabolism, Adult, Aged, Aldosterone/analogs & derivatives, Aldosterone/urine, Cadmium/urine, Cohort Studies, Family, Female, Gonadal Steroid Hormones/metabolism, Gonadal Steroid Hormones/urine, Humans, Hypertension/metabolism, Hypertension/urine, Kidney/metabolism, Male, Middle Aged, Mineralocorticoids/urine, Testosterone/urine
Pubmed
Web of science
Create date
03/11/2017 16:05
Last modification date
20/08/2019 14:01
Usage data