Human herpes-virus 8 seropositive patient with skin and graft Kaposi's sarcoma after lung transplantation.

Details

Serval ID
serval:BIB_4D19C088A716
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Human herpes-virus 8 seropositive patient with skin and graft Kaposi's sarcoma after lung transplantation.
Journal
Journal of the American Academy of Dermatology
Author(s)
Sachsenberg-Studer E.M., Dobrynski N., Sheldon J., Schulz T.F., Pechère M., Nador R.G., Spiliopoulos A., Nicod L., Saurat J.H.
ISSN
0190-9622[print], 0190-9622[linking]
Publication state
Published
Issued date
1999
Volume
40
Number
2 Pt 2
Pages
308-311
Language
english
Notes
Publication types: Case Reports ; Journal Article
Abstract
Kaposi's sarcoma (KS) has been reported after solid organ transplantation mostly in recipients of renal, liver, heart, and bone allografts. We describe the first case of a patient with lung transplantation who developed KS of the skin, but also of the lung graft. The tumors were localized to places of previous trauma, implying the involvement of a Koebner phenomenon. Moreover, a polymerase chain reaction assay revealed the presence of DNA sequences of herpesvirus 8 (HHV-8) on tissue of the cutaneous KS. Serological tests showed HHV-8 seronegativity of the graft donor and HHV-8 seropositivity of the patient before lung transplantation suggesting that the latter was already infected before the surgery and that immunosuppression resulted in the development of KS. This case report raises the question of the prevalence of HHV-8 in candidates for transplantation and organ donors, and of the value of an antiviral prophylaxis to lower the risk of KS.
Keywords
Herpesviridae Infections/diagnosis, Herpesviridae Infections/immunology, Herpesvirus 8, Human, Humans, Immunosuppression, Lung Neoplasms/diagnosis, Lung Neoplasms/immunology, Lung Transplantation/immunology, Male, Middle Aged, Opportunistic Infections/diagnosis, Opportunistic Infections/immunology, Polymerase Chain Reaction, Risk Factors, Sarcoma, Kaposi/diagnosis, Sarcoma, Kaposi/immunology, Skin Neoplasms/diagnosis, Skin Neoplasms/immunology
Pubmed
Web of science
Create date
19/02/2010 18:48
Last modification date
20/08/2019 14:01
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