Blood pressure and cognitive function: a prospective analysis among adolescents in Seychelles.

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Serval ID
serval:BIB_4CE2A9EA8D64
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Blood pressure and cognitive function: a prospective analysis among adolescents in Seychelles.
Journal
Journal of Hypertension
Author(s)
Lyngdoh T., Viswanathan B., Kobrosly R., van Wijngaarden E., Huber B., Davidson P.W., Cory-Slechta D.A., Strain S., Myers G.J., Bovet P.
ISSN
1473-5598 (Electronic)
ISSN-L
0263-6352
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
31
Number
6
Pages
1175-1182
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Abstract
OBJECTIVE: An inverse relationship between blood pressure (BP) and cognitive function has been found in adults, but limited data are available in adolescents and young adults. We examined the prospective relation between BP and cognitive function in adolescence.
METHODS: We examined the association between BP measured at the ages of 12-15 years in school surveys and cognitive endpoints measured in the Seychelles Child Development Study at ages 17 (n = 407) and 19 (n = 429) years, respectively. We evaluated multiple domains of cognition based on subtests of the Cambridge Neurological Test Automated Battery (CANTAB), the Woodcock Johnson Test of Scholastic Achievement (WJTA), the Finger Tapping test (FT) and the Kaufman Brief Intelligence Test (K-BIT). We used age, sex and height-specific z-scores of SBP, DBP and mean arterial pressure (MAP).
RESULTS: Six out of the 21 cognitive endpoints tested were associated with BP. However, none of these associations were found to hold for both males and females or for different subtests within the same neurodevelopmental domain or for both SBP and DBP. Most of these associations disappeared when analyses were adjusted for selected potential confounding factors such as socio-economic status, birth weight, gestational age, BMI, alcohol consumption, blood glucose, and total n-3 and n-6 polyunsaturated fats.
CONCLUSIONS: Our findings do not support a consistent association between BP and subsequent performance on tests assessing various cognitive domains in adolescents.
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Web of science
Create date
25/04/2013 11:15
Last modification date
20/08/2019 14:01
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