Fractal analysis of surfactant deposition in rabbit lungs

Details

Serval ID
serval:BIB_4CC60EAFCB3C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Fractal analysis of surfactant deposition in rabbit lungs
Journal
Journal of Applied Physiology
Author(s)
Gilliard  N., Pappert  D., Spragg  R. G.
ISSN
8750-7587 (Print)
Publication state
Published
Issued date
03/1995
Volume
78
Number
3
Pages
862-6
Notes
Journal Article
Research Support, U.S. Gov't, P.H.S. --- Old month value: Mar
Abstract
The effect of exogenous surfactant in the treatment of acute lung injury may depend on homogeneity of distribution of the material delivered. Analyses of distribution rely on sectioning the lung, determining surfactant concentration for each piece, and describing the variation in that value. Results of such analyses are influenced by how finely the lung is sectioned. We have reanalyzed data from prior experiments to determine whether the distribution of administered surfactant is fractal, that is, is independent of the scale of measurement. Lungs from animals receiving surfactant radiolabeled with [3H]dipalmitoylphosphatidylcholine were cut into 108 pieces, and the normalized radioactivity in each piece was determined. Sectioning of the lungs into different numbers of pieces (n = 2, 6, 12, 18, 36, 54, or 108) was simulated, and corresponding radioactivity contents were calculated. The coefficient of variation (CV) of these normalized values was then calculated for each scale of measurement (expressed as relative piece volume), and ln(CV) was plotted as a function of the logarithm of relative piece volume. These relationships were linear (average correlation coefficient = 0.96) for all animals, consistent with CV being a fractal property. We conclude that the intrapulmonary distribution of surfactant may be fractal and is therefore a property of the lung. This study demonstrates the utility of fractal analysis in describing the pulmonary distribution of substances introduced via the airway.
Keywords
Algorithms Animals Cattle *Fractals Lung/*metabolism Models, Biological Pulmonary Surfactants/*metabolism Rabbits Tissue Distribution
Pubmed
Web of science
Create date
28/01/2008 10:50
Last modification date
20/08/2019 14:01
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