Acinar Cell Carcinoma of the Pancreas: Overview of Clinicopathologic Features and Insights into the Molecular Pathology.

Details

Serval ID
serval:BIB_4CA7F1181B0C
Type
Article: article from journal or magazin.
Collection
Publications
Title
Acinar Cell Carcinoma of the Pancreas: Overview of Clinicopathologic Features and Insights into the Molecular Pathology.
Journal
Frontiers In Medicine
Author(s)
La Rosa S., Sessa F., Capella C.
ISSN
2296-858X (Electronic)
ISSN-L
2296-858X
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
2
Pages
41
Language
english
Notes
Publication types: Journal Article ; ReviewPublication Status: epublish
Abstract
Acinar cell carcinomas (ACCs) of the pancreas are rare pancreatic neoplasms accounting for about 1-2% of pancreatic tumors in adults and about 15% in pediatric subjects. They show different clinical symptoms at presentation, different morphological features, different outcomes, and different molecular alterations. This heterogeneous clinicopathological spectrum may give rise to difficulties in the clinical and pathological diagnosis with consequential therapeutic and prognostic implications. The molecular mechanisms involved in the onset and progression of ACCs are still not completely understood, although in recent years, several attempts have been made to clarify the molecular mechanisms involved in ACC biology. In this paper, we will review the main clinicopathological and molecular features of pancreatic ACCs of both adult and pediatric subjects to give the reader a comprehensive overview of this rare tumor type.
Pubmed
Open Access
Yes
Create date
06/09/2016 11:49
Last modification date
20/08/2019 14:01
Usage data