Tcf1<sup>+</sup> cells are required to maintain the inflationary T cell pool upon MCMV infection.

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Ressource 1Download: Welten 2020.pdf (2520.33 [Ko])
State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_4C6B9A0F8CD8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Tcf1<sup>+</sup> cells are required to maintain the inflationary T cell pool upon MCMV infection.
Journal
Nature communications
Author(s)
Welten SPM, Yermanos A., Baumann N.S., Wagen F., Oetiker N., Sandu I., Pedrioli A., Oduro J.D., Reddy S.T., Cicin-Sain L., Held W., Oxenius A.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
08/05/2020
Peer-reviewed
Oui
Volume
11
Number
1
Pages
2295
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Cytomegalovirus-based vaccine vectors offer interesting opportunities for T cell-based vaccination purposes as CMV infection induces large numbers of functional effector-like cells that accumulate in peripheral tissues, a process termed memory inflation. Maintenance of high numbers of peripheral CD8 T cells requires continuous replenishment of the inflationary T cell pool. Here, we show that the inflationary T cell population contains a small subset of cells expressing the transcription factor Tcf1. These Tcf1 <sup>+</sup> cells resemble central memory T cells and are proliferation competent. Upon sensing viral reactivation events, Tcf1 <sup>+</sup> cells feed into the pool of peripheral Tcf1 <sup>-</sup> cells and depletion of Tcf1 <sup>+</sup> cells hampers memory inflation. TCR repertoires of Tcf1 <sup>+</sup> and Tcf1 <sup>-</sup> populations largely overlap, with the Tcf1 <sup>+</sup> population showing higher clonal diversity. These data show that Tcf1 <sup>+</sup> cells are necessary for sustaining the inflationary T cell response, and upholding this subset is likely critical for the success of CMV-based vaccination approaches.
Keywords
Animals, CD8-Positive T-Lymphocytes/immunology, Cell Proliferation, Clone Cells, Herpesviridae Infections/immunology, Herpesviridae Infections/virology, Immunologic Memory, Interferon Type I/metabolism, Interleukin-12/metabolism, Mice, Inbred C57BL, Muromegalovirus/physiology, Phenotype, T Cell Transcription Factor 1/metabolism, T-Lymphocytes/immunology, T-Lymphocytes/virology
Pubmed
Web of science
Open Access
Yes
Create date
15/06/2020 14:49
Last modification date
18/09/2020 5:24
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