Macular Choroidal Thickening in Keratoconus Patients: Swept-Source Optical Coherence Tomography Study.

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Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_4C67905D11FD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Macular Choroidal Thickening in Keratoconus Patients: Swept-Source Optical Coherence Tomography Study.
Journal
Translational vision science & technology
Author(s)
Gutierrez-Bonet R., Ruiz-Medrano J., Peña-Garcia P., Catanese M., Sadeghi Y., Hashemi K., Gabison E., Ruiz-Moreno J.M.
ISSN
2164-2591 (Print)
ISSN-L
2164-2591
Publication state
Published
Issued date
05/2018
Peer-reviewed
Oui
Volume
7
Number
3
Pages
15
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
To determine the choroidal thickness (CT) profile in keratoconus (KC) patients using swept-source optical coherence tomography (SS-OCT).
This was a prospective, cross-sectional study. One hundred two eyes of 52 KC patients were studied using Pentacam and SS-OCT. The macular CT profile was created by manually measuring the distance between the retinal pigment epithelium and the choroid-sclera junction on horizontal b-scans at nine different macular locations. The results were compared to 93 eyes of 93 healthy controls.
Mean age of the KC group was 34.9 ± 13.5 years and mean axial length (AL) was 24.1 ± 1.3 mm. Mean topographic KC classification (TKC) was 2.0; 39 eyes were classified as early KC (TKC <1-2), 34 eyes as moderate (TKC 2, 2-3), and 29 as advanced (TKC 3+). Mean subfoveal CT was 383.2 μm in KC patients and 280.5 μm in control group ( <i>P</i> < 0.001). CT in KC patients was statistically thicker in all measure locations ( <i>P</i> < 0.001). CT in KC eyes decreased with age, approaching control group at >45 years old, losing statistical significance ( <i>P</i> = 0.37).
CT in KC patients is statistically thicker than in healthy population. After age 45, CT decreases approaching control group values.
This study describes changes in the CT profile of KC patients, a disease that was considered purely corneal. These choroidal changes argue that KC is a disease that likely involves several ocular structures other than the cornea, and could open new research lines related to the pathophysiology of KC.
Keywords
SS-OCT, choroid, choroidal thickness, keratoconus, swept-source OCT
Pubmed
Web of science
Create date
25/06/2018 10:34
Last modification date
20/08/2019 14:00
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