Risk factors for heart failure hospitalizations among patients with atrial fibrillation.

Details

Serval ID
serval:BIB_4C4E882B1D34
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Risk factors for heart failure hospitalizations among patients with atrial fibrillation.
Journal
PloS one
Author(s)
Eggimann L., Blum S., Aeschbacher S., Reusser A., Ammann P., Erne P., Moschovitis G., Di Valentino M., Shah D., Schläpfer J., Mondet N., Kühne M., Sticherling C., Osswald S., Conen D.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Publication state
Published
Issued date
2018
Peer-reviewed
Oui
Volume
13
Number
2
Pages
e0191736
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Patients with atrial fibrillation (AF) have an increased risk for the development of heart failure (HF). In this study, we aimed to detect predictors of HF hospitalizations in an unselected AF population.
The Basel Atrial Fibrillation Cohort Study is an ongoing observational multicenter cohort study in Switzerland. For this analysis, 1193 patients with documented AF underwent clinical examination, venous blood sampling and resting 12-lead ECG at baseline. Questionnaires about lifestyle and medical history were obtained in person at baseline and during yearly follow-up phone calls. HF hospitalizations were validated by two independent physicians. Cox regression analyses were performed using a forward selection strategy.
Overall, 29.8% of all patients were female and mean age was 69 ±12 years. Mean follow-up time was 3.7 ±1.5 years. Hospitalization for HF occurred in 110 patients, corresponding to an incidence of 2.5 events per 100 person years of follow-up. Independent predictors for HF were body mass index (HR 1.40 [95%CI 1.17; 1.66], p = 0.0002), chronic kidney disease (2.27 [1.49; 3.45], p = 0.0001), diabetes mellitus (2.13 [1.41; 3.24], p = 0.0004), QTc interval (1.25 [1.04; 1.49], p = 0.02), brain natriuretic peptide (2.19 [1.73; 2.77], p<0.0001), diastolic blood pressure (0.79 [0.65; 0.96], p = 0.02), history of pulmonary vein isolation or electrical cardioversion (0.54 [0.36; 0.80], p = 0.003) and serum chloride (0.82 [0.70; 0.96], p = 0.02).
In this unselected AF population, several traditional cardiovascular risk factors and arrhythmia interventions predicted HF hospitalizations, providing potential opportunities for the implementation of strategies to reduce HF among AF patients.

Keywords
Aged, Atrial Fibrillation/complications, Female, Heart Failure/etiology, Heart Failure/therapy, Hospitalization, Humans, Male, Middle Aged, Prospective Studies, Risk Factors
Pubmed
Web of science
Open Access
Yes
Create date
27/02/2018 8:20
Last modification date
20/08/2019 14:00
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