Hominoid fission of chromosome 14/15 and the role of segmental duplications.

Details

Serval ID
serval:BIB_4C035F54B0D4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Hominoid fission of chromosome 14/15 and the role of segmental duplications.
Journal
Genome Research
Author(s)
Giannuzzi G., Pazienza M., Huddleston J., Antonacci F., Malig M., Vives L., Eichler E.E., Ventura M.
ISSN
1549-5469 (Electronic)
ISSN-L
1088-9051
Publication state
Published
Issued date
2013
Volume
23
Number
11
Pages
1763-1773
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Ape chromosomes homologous to human chromosomes 14 and 15 were generated by a fission event of an ancestral submetacentric chromosome, where the two chromosomes were joined head-to-tail. The hominoid ancestral chromosome most closely resembles the macaque chromosome 7. In this work, we provide insights into the evolution of human chromosomes 14 and 15, performing a comparative study between macaque boundary region 14/15 and the orthologous human regions. We construct a 1.6-Mb contig of macaque BAC clones in the region orthologous to the ancestral hominoid fission site and use it to define the structural changes that occurred on human 14q pericentromeric and 15q subtelomeric regions. We characterize the novel euchromatin-heterochromatin transition region (∼20 Mb) acquired during the neocentromere establishment on chromosome 14, and find it was mainly derived through pericentromeric duplications from ancestral hominoid chromosomes homologous to human 2q14-qter and 10. Further, we show a relationship between evolutionary hotspots and low-copy repeat loci for chromosome 15, revealing a possible role of segmental duplications not only in mediating but also in "stitching" together rearrangement breakpoints.
Pubmed
Web of science
Open Access
Yes
Create date
15/12/2013 16:53
Last modification date
20/08/2019 15:00
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