Selectivity of the photosensitiser Tookad for photodynamic therapy evaluated in the Syrian golden hamster cheek pouch tumour model.

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State: Public
Version: Final published version
Serval ID
serval:BIB_4BE2442BE03E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Selectivity of the photosensitiser Tookad for photodynamic therapy evaluated in the Syrian golden hamster cheek pouch tumour model.
Journal
British journal of cancer
Author(s)
Borle F., Radu A., Fontolliet C., van den Bergh H., Monnier P., Wagnières G.
ISSN
0007-0920 (Print)
ISSN-L
0007-0920
Publication state
Published
Issued date
15/12/2003
Peer-reviewed
Oui
Volume
89
Number
12
Pages
2320-2326
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The response to photodynamic therapy (PDT) with the photosensitiser (PS) Tookad was measured in the Syrian hamster cheek pouch model on normal mucosae and chemically induced squamous cell carcinoma. This PS is a palladium-bacteriopheophorbide presenting absorption peaks at 538 and 762 nm. The light dose, drug dose and drug injection-light irradiation times (DLI), ranging between 100 and 300 J cm(-2), 1-5 mg kg(-1) and 10-240 min respectively, were varied and the response to PDT was analysed by staging the macroscopic response and by the histological examination of the sections of the irradiated cheek pouch. A fast time decay of the tissular response with drug dose of 1-5 mg kg(-1) was observed for DLI ranging from 10 to 240 min and for light doses of 100-300 J cm(-2) delivered at a light dose rate of 150 mW cm(-2). A significantly higher level of tissular response was observed for squamous cell carcinoma compared to normal tissue. Nevertheless, the threshold level of the drug-light dose for a detectable response was not significantly different in the tumoral vs normal tissue. The highest response at the shortest DLIs and the absence of measurable response at DLI larger than 240 min at light dose of 300 J cm(-2) and drug dose of 5 mg kg(-1) reveals the predominantly vascular effect of Tookad. This observation suggests that Tookad could be effective in PDT of vascularised lesions.

Keywords
9,10-Dimethyl-1,2-benzanthracene/adverse effects, Animals, Bacteriochlorophylls/administration & dosage, Carcinoma, Squamous Cell/chemically induced, Carcinoma, Squamous Cell/drug therapy, Cheek, Cricetinae, Dose-Response Relationship, Drug, Male, Mesocricetus, Models, Animal, Mouth Mucosa/drug effects, Mouth Mucosa/radiation effects, Mouth Neoplasms/chemically induced, Mouth Neoplasms/drug therapy, Photochemotherapy, Photosensitizing Agents/administration & dosage
Pubmed
Web of science
Open Access
Yes
Create date
29/01/2008 19:35
Last modification date
20/08/2019 15:00
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