Inter-informant agreement and prevalence estimates for mood syndromes: Direct interview vs. family history method.

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State: Public
Version: author
Serval ID
serval:BIB_4BD305075CC2
Type
Article: article from journal or magazin.
Collection
Publications
Title
Inter-informant agreement and prevalence estimates for mood syndromes: Direct interview vs. family history method.
Journal
Journal of Affective Disorders
Author(s)
Vandeleur C.L., Rothen S., Lustenberger Y., Glaus J., Castelao E., Preisig M.
ISSN
1573-2517 (Electronic)
ISSN-L
0165-0327
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
171
Pages
120-127
Language
english
Abstract
BACKGROUND: The use of the family history method is recommended in family studies as a type of proxy interview of non-participating relatives. However, using different sources of information can result in bias as direct interviews may provide a higher likelihood of assigning diagnoses than family history reports. The aims of the present study were to: 1) compare diagnoses for threshold and subthreshold mood syndromes from interviews to those relying on information from relatives; 2) test the appropriateness of lowering the diagnostic threshold and combining multiple reports from the family history method to obtain comparable prevalence estimates to the interviews; 3) identify factors that influence the likelihood of agreement and reporting of disorders by informants.
METHODS: Within a family study, 1621 informant-index subject pairs were identified. DSM-5 diagnoses from direct interviews of index subjects were compared to those derived from family history information provided by their first-degree relatives.
RESULTS: 1) Inter-informant agreement was acceptable for Mania, but low for all other mood syndromes. 2) Except for Mania and subthreshold depression, the family history method provided significantly lower prevalence estimates. The gap improved for all other syndromes after lowering the threshold of the family history method. 3) Individuals who had a history of depression themselves were more likely to report depression in their relatives.
LIMITATIONS: Low proportion of affected individuals for manic syndromes and lack of independence of data.
CONCLUSIONS: The higher likelihood of reporting disorders by affected informants entails the risk of overestimation of the size of familial aggregation of depression.
Pubmed
Web of science
Create date
24/10/2014 9:52
Last modification date
20/08/2019 14:59
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