F-18-Dopa Positron Emission Tomography/Computed Tomography Is More Sensitive Than Whole-Body Magnetic Resonance Imaging for the Localization of Persistent/Recurrent Disease of Medullary Thyroid Cancer Patients.
Details
Serval ID
serval:BIB_4BBA95396E7B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
F-18-Dopa Positron Emission Tomography/Computed Tomography Is More Sensitive Than Whole-Body Magnetic Resonance Imaging for the Localization of Persistent/Recurrent Disease of Medullary Thyroid Cancer Patients.
Journal
Thyroid
ISSN
1557-9077 (Electronic)
ISSN-L
1050-7256
Publication state
Published
Issued date
10/2019
Peer-reviewed
Oui
Volume
29
Number
10
Pages
1457-1464
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Background: Elevated postoperative serum calcitonin (Ctn) level indicates persistent/recurrent disease in patients with medullary thyroid carcinoma (MTC). Its location is a challenge. The aim of our study was to compare the disease detection rates of F-18-Dopa (fluoro dihydroxyphenylalanine) positron emission tomography (PET)/computed tomography (CT), whole-body (WB) magnetic resonance imaging (MRI), F-18-FDG (fluorodeoxyglucose) PET/CT, WB CT scanning, neck ultrasonography, and bone scintigraphy in MTC patients with increased Ctn levels and unknown localization of the source. Methods: We compared the independent reading of each imaging procedure with a reference assessment for structural disease defined by pathology or concordance between two imagings or with subsequent follow-up. The detection rate of each imaging modality was determined in per patient, per organ, and per lesion analysis. Results: Thirty-six consecutive patients (21 females, mean age: 57 years, sporadic MTC in 26 cases, median serum Ctn level: 760 pg/mL; range: 21-10,121) were analyzed. The reference assessment localized disease in 24 (64%) patients with 74 lesions detected in the thyroid bed (8), in neck lymph nodes (15), mediastinal lymph nodes (6), lungs (1), liver (2), bones (3), and other site (1). At the patient level, the detection rates were 64% (CI 0.48-0.80) for F-18-Dopa PET/CT with early acquisitions, 40% (CI 0.24-0.56) for F-18-FDG PET/CT, 40% (CI 0.24-0.56) for WB MRI, and 48% (CI 0.31-0.66) for WB CT scan. Conclusions: In MTC patients with increased Ctn and no known distant metastases, F-18-Dopa PET/CT is more sensitive to detect structural disease than any other imaging modality, including WB MRI.
Keywords
Adult, Aged, Aged, 80 and over, Bone Neoplasms/diagnostic imaging, Bone Neoplasms/secondary, Bone and Bones/diagnostic imaging, Calcitonin/blood, Carcinoembryonic Antigen/blood, Carcinoma, Neuroendocrine/blood, Carcinoma, Neuroendocrine/diagnostic imaging, Carcinoma, Neuroendocrine/pathology, Carcinoma, Neuroendocrine/surgery, Dihydroxyphenylalanine/analogs & derivatives, Female, Fluorodeoxyglucose F18, Humans, Liver Neoplasms/diagnostic imaging, Liver Neoplasms/secondary, Lung Neoplasms/diagnostic imaging, Lung Neoplasms/secondary, Lymph Nodes/diagnostic imaging, Lymphatic Metastasis, Magnetic Resonance Imaging, Male, Mediastinum, Middle Aged, Neck, Neck Dissection, Neoplasm Metastasis, Neoplasm Recurrence, Local/diagnostic imaging, Positron Emission Tomography Computed Tomography, Radionuclide Imaging, Radiopharmaceuticals, Thyroid Neoplasms/blood, Thyroid Neoplasms/diagnostic imaging, Thyroid Neoplasms/pathology, Thyroid Neoplasms/surgery, Thyroidectomy, Ultrasonography, Whole Body Imaging, F-18-Dopa PET/CT, increased calcitonin, medullary thyroid carcinoma, whole-body MRI
Pubmed
Web of science
Create date
20/09/2019 21:27
Last modification date
24/02/2023 11:23