Cancer testis antigen expression in gastrointestinal stromal tumors: new markers for early recurrence.

Details

Serval ID
serval:BIB_4B506C1DD02B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cancer testis antigen expression in gastrointestinal stromal tumors: new markers for early recurrence.
Journal
International Journal of Cancer = Journal international du cancer
Author(s)
Perez D., Herrmann T., Jungbluth A.A., Samartzis P., Spagnoli G., Demartines N., Clavien P.A., Marino S., Seifert B., Jaeger D.
ISSN
1097-0215[electronic]
Publication state
Published
Issued date
2008
Volume
123
Number
7
Pages
1551-1555
Language
english
Abstract
Cancer testis antigens (CTAs) are expressed in a variety of malignant tumors but not in any normal adult tissues except germ cells and occasionally placenta. Because of this tumor-associated pattern of expression, CTAs are regarded as potential vaccine targets. The expression of CTAs in gastrointestinal stromal tumors (GIST) has not been analyzed systematically previously. The present study was performed to analyze the expression of CTA in GIST and to determine if CTA expression correlates with prognosis. Thirty-five GIST patients were retrospectively analyzed for their expression of CTAs by immunohistochemistry using the following monoclonal antibodies (mAb/antigen): MA454/MAGE-A1, M3H67/MAGE-A3, 57B/MAGE-A4, CT7-33/MAGE-C1 and E978/NY-ESO-1. Fourteen tumors (40%) expressed 1 or more of the 5 CTAs tested. Fourteen percent (n = 5/35) were positive for MAGE-A1, MAGE-A3 or MAGE-A4, respectively. Twenty-six percent (n = 9/35) stained positive for MAGE-C1 and 20% (n = 7/35) for NY-ESO-1. A highly significant correlation between CTA expression and tumor recurrence risk was observed (71% vs. 29%; p = 0.027). In our study population, the high-risk GIST expressed CTAs more frequently than low-risk GIST (p = 0.012). High-risk GISTs which stained positive for at least 1 CTA, recurred in 100% (n = 25) of the cases. This is the first study analyzing CTA expression in GIST and its prognostic value for recurrence. The CTA staining could add information to the individual patient prognosis and represent an interesting target for future treatment strategies.
Keywords
Adolescent, Adult, Aged, Aged, 80 and over, Antibodies, Monoclonal/immunology, Antigens, Neoplasm/immunology, Child, Disease-Free Survival, Female, Gastrointestinal Stromal Tumors/immunology, Gastrointestinal Stromal Tumors/pathology, Humans, Immunohistochemistry, Male, Middle Aged, Testis/immunology, Tumor Markers, Biological/immunology
Pubmed
Web of science
Open Access
Yes
Create date
03/10/2009 7:55
Last modification date
20/08/2019 13:59
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