Naltrexone-assisted rapid methadone discontinuation: a pilot study

Details

Serval ID
serval:BIB_4B49E5F5B9A3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Naltrexone-assisted rapid methadone discontinuation: a pilot study
Journal
European Addiction Research
Author(s)
Camarasa Xavier, Khazaal Yasser, Besson Jacques, Zullino Daniele Fabio
ISSN
1022-6877
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
13
Number
1
Pages
20-24
Language
english
Notes
SAPHIRID:61430
Abstract
Slow downtitration as a methadone discontinuation method is time-consuming and associated to high dropout rates. Whereas ultra-rapid opiate detoxification methods have recently gained some popularity, they are expensive and may be associated with particular problems in methadone patients. In the present study, a 3-day detoxification procedure accelerated with a unique dose of naltrexone was used in 10 methadone-substituted patients. Whereas the treatment resulted in a shortened withdrawal syndrome, which was satisfactorily controlled by the drugs used, a two-phase course was observed, some symptoms reappearing between the end of day 2 and the beginning of day 3. The first phase of withdrawal symptoms was attributed to the antagonistic effect of naltrexone, which possibly also improved under the weakening of naltrexone. The second phase of withdrawal symptoms may be related to falling methadone plasma levels
Pubmed
Web of science
Open Access
Yes
Create date
10/03/2008 10:43
Last modification date
20/08/2019 14:59
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