Convergent origination of a <i>Drosophila</i>-like dosage compensation mechanism in a reptile lineage.

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Ressource 1Download: Genome Res.-2017-Marin-1974-87.pdf (4450.59 [Ko])
State: Public
Version: Final published version
Serval ID
serval:BIB_4B08210A7372
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Convergent origination of a <i>Drosophila</i>-like dosage compensation mechanism in a reptile lineage.
Journal
Genome research
Author(s)
Marin R., Cortez D., Lamanna F., Pradeepa M.M., Leushkin E., Julien P., Liechti A., Halbert J., Brüning T., Mössinger K., Trefzer T., Conrad C., Kerver H.N., Wade J., Tschopp P., Kaessmann H.
ISSN
1549-5469 (Electronic)
ISSN-L
1088-9051
Publication state
Published
Issued date
12/2017
Peer-reviewed
Oui
Volume
27
Number
12
Pages
1974-1987
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Sex chromosomes differentiated from different ancestral autosomes in various vertebrate lineages. Here, we trace the functional evolution of the XY Chromosomes of the green anole lizard ( <i>Anolis carolinensis</i> ), on the basis of extensive high-throughput genome, transcriptome and histone modification sequencing data and revisit dosage compensation evolution in representative mammals and birds with substantial new expression data. Our analyses show that <i>Anolis</i> sex chromosomes represent an ancient XY system that originated at least ≈160 million years ago in the ancestor of Iguania lizards, shortly after the separation from the snake lineage. The age of this system approximately coincides with the ages of the avian and two mammalian sex chromosomes systems. To compensate for the almost complete Y Chromosome degeneration, X-linked genes have become twofold up-regulated, restoring ancestral expression levels. The highly efficient dosage compensation mechanism of <i>Anolis</i> represents the only vertebrate case identified so far to fully support Ohno's original dosage compensation hypothesis. Further analyses reveal that X up-regulation occurs only in males and is mediated by a male-specific chromatin machinery that leads to global hyperacetylation of histone H4 at lysine 16 specifically on the X Chromosome. The green anole dosage compensation mechanism is highly reminiscent of that of the fruit fly, <i>Drosophila melanogaster</i> Altogether, our work unveils the convergent emergence of a <i>Drosophila</i> -like dosage compensation mechanism in an ancient reptilian sex chromosome system and highlights that the evolutionary pressures imposed by sex chromosome dosage reductions in different amniotes were resolved in fundamentally different ways.
Keywords
Animals, Dosage Compensation, Genetic, Drosophila/genetics, Epigenesis, Genetic, Evolution, Molecular, Female, Genome, Humans, Lizards/genetics, Male, Sex Determination Processes, Transcriptome, X Chromosome, Y Chromosome
Pubmed
Web of science
Open Access
Yes
Create date
16/11/2017 22:28
Last modification date
20/08/2019 14:58
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