Occupational exposure to organic solvents and the risk of developing testicular germ cell tumors (TESTIS study): Effect of combined exposure assessment on risk estimation

Details

Serval ID
serval:BIB_4B051C0B8943
Type
Article: article from journal or magazin.
Collection
Publications
Title
Occupational exposure to organic solvents and the risk of developing testicular germ cell tumors (TESTIS study): Effect of combined exposure assessment on risk estimation
Journal
Scandinavian Journal of Work, Environment & Health
Author(s)
Guth Margot, Pilorget Corinne, Lefevre Marie, Coste Astrid, Danjou Aurélie, Dananché Brigitte, Praud Delphine, Pérol Olivia, Daudin Myriam, Clarotti Marie-Ange, Lattes Stéphanie, Bouillon Céline, Paul Adèle, Schüz Joachim, Bujan Louis, Olsson Ann, Fervers Béatrice, Charbotel Barbara
Working group(s)
The TESTIS study, group
Publication state
Published
Issued date
2024
Peer-reviewed
Oui
Language
english
Abstract
OBJECTIVES: Etiological factors of testicular germ cell tumors (TGCT) remain largely unknown, but a causal role of occupational exposures to solvents has been suggested. Previous studies analyzing these exposures reported discordant results, potentially related to exposure assessment methods. The aim of this study was to investigate the role of occupational exposure to solvents on the risk of developing TGCT among young men. METHODS: This study examined occupational exposures to solvents and TGCT risk based on the lifetime work histories of 454 cases and 670 controls, aged 18–45 years, of the French national TESTIS case–control study. Solvent exposure was estimated using: (i) exposure assignment by job-exposure matrix (JEM) and (ii) JEM combined with self-reported exposure data from specific questionnaires (SQ) and expert assessment (EA). Odds ratios (OR) and 95% confidence intervals (CI) were estimated using conditional logistic regression models. RESULTS: Both approaches (JEM and JEM+SQ+EA) showed a consistent association between TGCT and trichloroethylene exposure (exposed versus not exposed; JEM=OR 1.80 [95% confidence interval (CI) 1.12–2.90] and JEM+SQ+EA= OR 2.59 (95% CI 1.42–4.72). Both approaches also observed positive associations with ketone esters and fuels & petroleum-based solvents. CONCLUSION: The results suggest that some organic solvents might be involved in the pathogenesis of TGCT among occupationally exposed men. The combined use of JEM+SQ+EA seemed to limit misclassification by considering individual exposure variability and is, therefore, an appealing approach to assess occupational exposures in epidemiological studies.
Keywords
exposure assessment method, occupational health, risk assessment, testicular cancer, trichloroethylene
Create date
26/09/2024 10:11
Last modification date
27/09/2024 16:46
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