A Population-Based Model to Consider the Effect of Seasonal Variation on Serum 25(OH)D and Vitamin D Status.

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Serval ID
serval:BIB_4B02CCA3AA06
Type
Article: article from journal or magazin.
Collection
Publications
Title
A Population-Based Model to Consider the Effect of Seasonal Variation on Serum 25(OH)D and Vitamin D Status.
Journal
BioMed Research International
Author(s)
Vuistiner P., Rousson V., Henry H., Lescuyer P., Boulat O., Gaspoz J.M., Mooser V., Vollenweider P., Waeber G., Cornuz J., Paccaud F., Bochud M., Guessous I.
ISSN
2314-6141 (Electronic)
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
2015
Pages
168189
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Background. We elaborated a model that predicts the centiles of the 25(OH)D distribution taking into account seasonal variation. Methods. Data from two Swiss population-based studies were used to generate (CoLaus) and validate (Bus Santé) the model. Serum 25(OH)D was measured by ultra high pressure LC-MS/MS and immunoassay. Linear regression models on square-root transformed 25(OH)D values were used to predict centiles of the 25(OH)D distribution. Distribution functions of the observations from the replication set predicted with the model were inspected to assess replication. Results. Overall, 4,912 and 2,537 Caucasians were included in original and replication sets, respectively. Mean (SD) 25(OH)D, age, BMI, and % of men were 47.5 (22.1) nmol/L, 49.8 (8.5) years, 25.6 (4.1) kg/m(2), and 49.3% in the original study. The best model included gender, BMI, and sin-cos functions of measurement day. Sex- and BMI-specific 25(OH)D centile curves as a function of measurement date were generated. The model estimates any centile of the 25(OH)D distribution for given values of sex, BMI, and date and the quantile corresponding to a 25(OH)D measurement. Conclusions. We generated and validated centile curves of 25(OH)D in the general adult Caucasian population. These curves can help rank vitamin D centile independently of when 25(OH)D is measured.
Pubmed
Web of science
Open Access
Yes
Create date
05/10/2015 13:10
Last modification date
20/08/2019 13:58
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