Turning tumors from cold to inflamed to improve immunotherapy response.

Details

Serval ID
serval:BIB_4AB33FCA1873
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Turning tumors from cold to inflamed to improve immunotherapy response.
Journal
Cancer treatment reviews
Author(s)
Gerard C.L., Delyon J., Wicky A., Homicsko K., Cuendet M.A., Michielin O.
ISSN
1532-1967 (Electronic)
ISSN-L
0305-7372
Publication state
Published
Issued date
19/05/2021
Peer-reviewed
Oui
Volume
101
Pages
102227
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: aheadofprint
Abstract
Immune checkpoint inhibitors have revolutionized the treatment landscape for a number of cancers over the last few decades. Nevertheless, a majority of patients still do not benefit from these treatments. Such patient-specific lack of response can be predicted, in part, from the immune phenotypes present in the tumor microenvironment. We provide a perspective on options to reprogram the tumors and their microenvironment to increase the therapeutic efficacy of immunotherapies and expand their efficacy against cold tumors. Additionally, we review data from current preclinical and clinical trials aimed at testing the different therapeutic options in monotherapy or preferably in combination with checkpoint inhibitors.
Keywords
Cold tumors, Hot tumors, Immunotherapy, Inflamed tumors, Tumor microenvironment
Pubmed
Web of science
Create date
25/10/2021 9:44
Last modification date
19/11/2021 7:40
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