Management of Hyperuricemia in Patients with Chronic Kidney Disease: a Focus on Renal Protection.

Details

Serval ID
serval:BIB_4AA06E8E5DBB
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Management of Hyperuricemia in Patients with Chronic Kidney Disease: a Focus on Renal Protection.
Journal
Current hypertension reports
Author(s)
Kielstein J.T., Pontremoli R., Burnier M.
ISSN
1534-3111 (Electronic)
ISSN-L
1522-6417
Publication state
Published
Issued date
31/10/2020
Peer-reviewed
Oui
Volume
22
Number
12
Pages
102
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
In chronic kidney disease (CKD), plasma uric acid levels are increased because of the decrease in glomerular filtration rate. However, in addition to CKD, hyperuricemia is frequently associated with a number of other conditions such as hypertension, type 2 diabetes, obesity, and heart failure, overweight, and cardiovascular disease.
It is now becoming increasingly clear that, in many clinical conditions, elevated levels of uric acid have a much greater role beyond just causing gout. The present review will summarize current knowledge on the relation between hyperuricemia, CKD, and existing comorbidities, as well as the mechanisms of uric acid-related renal damage. In addition, the role and evidence for urate-lowering therapy in prevention and cardiovascular protection in CKD patients is discussed with a focus on allopurinol and febuxostat. To date, several clinical studies have provided evidence that urate-lowering therapy may help to prevent and delay the decline of renal function in patients with CKD. Use of a xanthine oxidase inhibitor should be considered in patients who are at high renal risk and/or with declining renal function in the presence of hyperuricemia with and without deposition, although additional studies are warranted to define treatment targets. Notwithstanding, the possibility to delay deterioration of renal function in patients with CKD merits consideration.
Keywords
Allopurinol, Chronic kidney disease, Febuxostat, Hypertension, Hyperuricemia, Renal protection, Urate-lowering therapy
Pubmed
Web of science
Open Access
Yes
Create date
09/11/2020 10:44
Last modification date
23/02/2022 7:36
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