Modulatory effects of 5Hz rTMS over the primary somatosensory cortex in focal dystonia--an fMRI-TMS study.

Details

Serval ID
serval:BIB_4A9A7C931D62
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Modulatory effects of 5Hz rTMS over the primary somatosensory cortex in focal dystonia--an fMRI-TMS study.
Journal
Movement Disorders
Author(s)
Schneider S.A., Pleger B., Draganski B., Cordivari C., Rothwell J.C., Bhatia K.P., Dolan R.J.
ISSN
1531-8257 (Electronic)
ISSN-L
0885-3185
Publication state
Published
Issued date
2010
Volume
25
Number
1
Pages
76-83
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
Dystonia is associated with impaired somatosensory ability. The electrophysiological method of repetitive transcranial magnetic stimulation (rTMS) can be used for noninvasive stimulation of the human cortex and can alter cortical excitability and associated behavior. Among others, rTMS can alter/improve somatosensory discrimation abilities, as shown in healthy controls. We applied 5Hz-rTMS over the left primary somatosensory cortex (S1) in 5 patients with right-sided writer's dystonia and 5 controls. We studied rTMS effects on tactile discrimination accuracy and concomitant rTMS-induced changes in hemodynamic activity measured by functional magnetic resonance imaging (fMRI). Before rTMS, patients performed worse on the discrimination task than controls even though fMRI showed greater task-related activation bilaterally in the basal ganglia (BG). In controls, rTMS led to improved discrimination; fMRI revealed this was associated with increased activity of the stimulated S1, bilateral premotor cortex and BG. In dystonia patients, rTMS had no effect on discrimination; fMRI showed similar cortical effects to controls except for no effects in BG. Improved discrimination after rTMS in controls is linked to enhanced activation of S1 and BG. Failure of rTMS to increase BG activation in dystonia may be associated with the lack of effect on sensory discrimination in this group and may reflect impaired processing in BG-S1 connections. Alternatively, the increased BG activation seen in the baseline state without rTMS may reflect a compensatory strategy that saturates a BG contribution to this task.
Keywords
Adult, Aged, Aged, 80 and over, Brain Mapping, Discrimination (Psychology)/physiology, Dystonic Disorders/pathology, Dystonic Disorders/physiopathology, Evoked Potentials, Somatosensory/physiology, Female, Humans, Image Processing, Computer-Assisted/methods, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Oxygen/blood, Somatosensory Cortex/blood supply, Somatosensory Cortex/physiopathology, Statistics, Nonparametric, Transcranial Magnetic Stimulation/methods
Pubmed
Web of science
Open Access
Yes
Create date
09/02/2011 13:27
Last modification date
20/08/2019 13:58
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