Angiogenesehemmung in der Neuroonkologie. Eine vielversprechende Therapiestrategie gegen maligne Gliome [Angiogenesis inhibition in neurooncology. A very promising therapy strategy for malignant glioma]

Details

Serval ID
serval:BIB_4A8756B86657
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Angiogenesehemmung in der Neuroonkologie. Eine vielversprechende Therapiestrategie gegen maligne Gliome [Angiogenesis inhibition in neurooncology. A very promising therapy strategy for malignant glioma]
Journal
Der Nervenarzt
Author(s)
Tabatabai G., Stupp R.
ISSN
1433-0407[electronic], 0028-2804[linking]
Publication state
Published
Issued date
2010
Volume
81
Number
8
Pages
936-939
Language
german
Abstract
The application of angiogenesis inhibitors in neurooncology is increasing. Initially, these drugs seemed to be very promising because of the surprisingly high neuroradiological response rates that were observed in first clinical trials. Meanwhile, this enthusiasm is waning, as the high response rates did not translate into substantial improvements in progression-free and overall survival. Tumor progression during or after antiangiogenic therapy is often associated with rapid clinical neurological deterioration and sometimes even with diffuse infiltrative gliomatosis-like neuroradiological phenotypes. Thus, the characterization and understanding of escape mechanisms are needed. The identification of criteria for defining the personalized use of angiogenesis inhibitors remains a challenge.
Keywords
Neurooncology, Angiogenesis inhibition, Vascular endothelial growth factor, Resistance mechanisms, Phenotype, recurrent glioblastoma-multiforme, bevacizumab plus irinotecan, endothelial growth-factor, malignant gliomas, phase-ii, tumor vasculature, kinase inhibitor, cilengitide, cells, temozolomide
Pubmed
Web of science
Create date
01/09/2010 13:08
Last modification date
20/08/2019 13:58
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