Great ape DNA sequences reveal a reduced diversity and an expansion in humans.

Details

Serval ID
serval:BIB_4A6C6DB5C4E1
Type
Article: article from journal or magazin.
Collection
Publications
Title
Great ape DNA sequences reveal a reduced diversity and an expansion in humans.
Journal
Nature Genetics
Author(s)
Kaessmann H., Wiebe V., Weiss G., Pääbo S.
ISSN
1061-4036 (Print)
ISSN-L
1061-4036
Publication state
Published
Issued date
2001
Volume
27
Number
2
Pages
155-156
Language
english
Abstract
The extent of DNA sequence variation of chimpanzees is several-fold greater than that of humans. It is unclear, however, if humans or chimpanzees are exceptional among primates in having low and high amounts of DNA sequence diversity, respectively. To address this, we have determined approximately 10,000 bp of noncoding DNA sequences at Xq13.3 (which has been extensively studied in both humans and chimpanzees) from 10 western lowland gorillas (Gorilla gorilla gorilla) and 1 mountain gorilla (Gorilla gorilla beringei; that is, from 2 of the 3 currently recognized gorilla subspecies), as well as 8 Bornean (Pongo pygmaeus pygmaeus) and 6 Sumatran (Pongo pygmaeus abelii) orang-utans, representing both currently recognized orang-utan subspecies. We show that humans differ from the great apes in having a low level of genetic variation and a signal of population expansion.
Keywords
Animals, Genetic Variation, Gorilla gorilla/classification, Gorilla gorilla/genetics, Hominidae/classification, Hominidae/genetics, Humans, Phylogeny, Pongo pygmaeus/classification, Pongo pygmaeus/genetics, X Chromosome/genetics
Pubmed
Web of science
Create date
24/01/2008 15:41
Last modification date
20/08/2019 13:58
Usage data