Updated review of postmortem biochemical exploration of hypothermia with a presentation of standard strategy of sampling and analyses.

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State: Public
Version: Final published version
Serval ID
serval:BIB_4A680652B55D
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Updated review of postmortem biochemical exploration of hypothermia with a presentation of standard strategy of sampling and analyses.
Journal
Clinical chemistry and laboratory medicine
Author(s)
Rousseau G., Reynier P., Jousset N., Rougé-Maillart C., Palmiere C.
ISSN
1437-4331 (Electronic)
ISSN-L
1434-6621
Publication state
Published
Issued date
25/10/2018
Peer-reviewed
Oui
Volume
56
Number
11
Pages
1819-1827
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Hypothermia is defined as a core body temperature below 35°C and can be caused by environmental exposure, drug intoxication, metabolic or nervous system dysfunction. This lethal pathology with medico-legal implications is complex to diagnose because macroscopic and microscopic lesions observed at the autopsy and the histological analysis are suggestive but not pathognomonic. Postmortem biochemical explorations have been progressively developed through the study of several biomarkers to improve the diagnosis decision cluster. Here, we present an updated review with novel biomarkers (such as catecholamines O-methylated metabolites, thrombomodulin and the cardiac oxyhemoglobin ratio) as well as some propositional interpretative postmortem thresholds and, to the best of our knowledge, for the first time, we present the most adapted strategy of sampling and analyses to identify biomarkers of hypothermia. For our consideration, the most relevant identified biomarkers are urinary catecholamines and their O-methylated metabolites, urinary free cortisol, blood cortisol, as well as blood, vitreous humor and pericardial fluid for ketone bodies and blood free fatty acids. These biomarkers are increased in response either to cold-mediated stress or to bioenergetics ketogenesis crisis and significantly contribute to the diagnosis by exclusion of death by hypothermia.
Keywords
biochemistry, biomarkers, forensic, hypothermia, postmortem
Pubmed
Web of science
Open Access
Yes
Create date
02/05/2018 13:54
Last modification date
20/08/2019 13:58
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