Lithium concentrations in saliva, plasma and red blood cells of patients given lithium acetate.
Details
Serval ID
serval:BIB_4A5271796AAC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Lithium concentrations in saliva, plasma and red blood cells of patients given lithium acetate.
Journal
Acta psychiatrica Scandinavica
ISSN
0001-690X (Print)
ISSN-L
0001-690X
Publication state
Published
Issued date
07/1978
Peer-reviewed
Oui
Volume
58
Number
1
Pages
67-79
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Lithium concentrations in saliva, plasma and red blood cells were measured in: 1) six hospitalized patients under long-term lithium therapy, at 2, 5, 9 and 24 hours after oral doses of 24 mEq Li acetate and 2 or 12 hours after 8 mEq Li acetate; and 2) 10 outpatients under chronic lithium treatment at two occasions 8 days apart. With changing plasma concentrations, [Li] saliva varied without any notable time lag. [Li] saliva was always much higher than [Li] plasma. The ratio [Li] saliva/ [Li] plasma water averaged 3.2 +/- 0.2 in 62 determinations, but varied widely at different times after oral lithium in the same individuals and less widely between different individuals. "Prediction" of plasma lithium concentration from measured [Li] saliva appears hazardous, and may provide reliable indications only if [Li] saliva is measured repeatedly. Salivary lithium concentrations were not correlated with either potassium or sodium concentrations. Lithium concentrations in red blood cells were always lower than in plasma: [Li] red blood cell water/ [Li] plasma water averaged 0.37 +/- 0.03. With changing plasma concentrations, rise and fall of red blood cell lithium lagged considerably behind plasma changes. This resulted in a rise of the red blood cell/plasma concentration ratio from a very low value 2 hours after an oral dose to a rather high value 24 hours after an oral dose.
Keywords
Administration, Oral, Adult, Aged, Erythrocytes/metabolism, Humans, Lithium/administration & dosage, Lithium/blood, Lithium/metabolism, Mental Disorders/drug therapy, Middle Aged, Potassium/metabolism, Saliva/analysis, Sodium/metabolism, Time Factors
Pubmed
Web of science
Create date
11/01/2021 12:34
Last modification date
15/04/2023 6:51