Acute gout: The inflammasome.

Details

Serval ID
serval:BIB_4A4FC3D033E7
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Acute gout: The inflammasome.
Journal
Current Rheumatology Reviews
Author(s)
Guarda G., Yazdi A.S., D'Ombrain M.C., Drexler S.K.
ISSN
1875-6360
ISSN-L
1573-3971
Publication state
Published
Issued date
2011
Volume
7
Number
2
Pages
132-140
Language
english
Abstract
Gout is one of the most common and painful forms of arthritis in humans with a growing incidence and prevalence over the last decades. Recent studies into the pathophysiology of acute gout have revealed that MSU (monosodium urate), the crystalline form of uric acid, is recognized by immune cells as a danger signal and can initiate an inflammatory response. This response is orchestrated by the intracellular pattern-recognition receptor NLRP3, which upon exposure to MSU, forms a cytosolic multiprotein-complex called the inflammasome, leading to the activation of caspase- 1. Caspase-1 then cleaves the highly pro-inflammatory cytokines interleukin (IL)-1β and IL-18, leading to the secretion of their biologically active forms and culminating in an acute gout attack. This newfound molecular understanding of the pathology of gout has seen the introduction of IL-1 inhibitors as an improved treatment for acute gout with reduced side effects compared to conventional gout therapies.
Keywords
IL-1β, Lesch-Nyhan-Syndrome, SLC2A9, Uric acid, Xenopus oocytes, caspase-1, hyperuricemia, inflammasome, leukemias, monosodium urate, polycythemia
Create date
13/03/2012 15:51
Last modification date
20/08/2019 13:58
Usage data