Evidence for corticofugal modulation of peripheral auditory activity in humans

Details

Serval ID
serval:BIB_4A4E4C64C541
Type
Article: article from journal or magazin.
Collection
Publications
Title
Evidence for corticofugal modulation of peripheral auditory activity in humans
Journal
Cereb Cortex
Author(s)
Perrot X., Ryvlin P., Isnard J., Guenot M., Catenoix H., Fischer C., Mauguiere F., Collet L.
ISSN
1047-3211 (Print)
ISSN-L
1047-3211
Publication state
Published
Issued date
07/2006
Volume
16
Number
7
Pages
941-8
Language
english
Notes
Perrot, Xavier
Ryvlin, Philippe
Isnard, Jean
Guenot, Marc
Catenoix, Helene
Fischer, Catherine
Mauguiere, Francois
Collet, Lionel
eng
Clinical Trial
Cereb Cortex. 2006 Jul;16(7):941-8. doi: 10.1093/cercor/bhj035. Epub 2005 Sep 8.
Abstract
Active cochlear micromechanisms, involved in auditory sensitivity, are modulated by the medial olivocochlear efferent system, which projects directly onto the organ of Corti. Both processes can be assessed non-invasively by means of evoked otoacoustic emissions. Animal experiments have revealed top-down control from the auditory cortex to peripheral auditory receptor, supported by anatomical descriptions of descending auditory pathways from auditory areas to the medial olivocochlear efferent system and organ of Corti. Through recording of evoked otoacoustic emissions during presurgical functional brain mapping for refractory epilepsy, we showed that corticofugal modulation of peripheral auditory activity also exists in humans. In 10 epileptic patients, electrical stimulation of the contralateral auditory cortex led to a significant decrease in evoked otoacoustic emission amplitude, whereas no change occurred under stimulation of non-auditory contralateral areas. These findings provide evidence of a cortico-olivocochlear pathway, originating in the auditory cortex and modulating contralateral active cochlear micromechanisms via the medial olivocochlear efferent system, in humans.
Keywords
*Action Potentials, Adaptation, Physiological, Adult, Auditory Cortex/*physiopathology, Electric Stimulation, Epilepsy/*physiopathology, Evidence-Based Medicine, *Evoked Potentials, Auditory, Female, Humans, Male, Neural Pathways/physiopathology, Neuronal Plasticity, Olivary Nucleus/*physiopathology, Otoacoustic Emissions, Spontaneous
Pubmed
Open Access
Yes
Create date
29/11/2018 12:37
Last modification date
20/08/2019 13:57
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