Vitamin D: Nutrient, Hormone, and Immunomodulator.

Details

Serval ID
serval:BIB_4A47193D3E42
Type
Article: article from journal or magazin.
Collection
Publications
Title
Vitamin D: Nutrient, Hormone, and Immunomodulator.
Journal
Nutrients
Author(s)
Sassi F., Tamone C., D'Amelio P.
ISSN
2072-6643 (Electronic)
ISSN-L
2072-6643
Publication state
Published
Issued date
03/11/2018
Peer-reviewed
Oui
Volume
10
Number
11
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
The classical functions of vitamin D are to regulate calcium-phosphorus homeostasis and control bone metabolism. However, vitamin D deficiency has been reported in several chronic conditions associated with increased inflammation and deregulation of the immune system, such as diabetes, asthma, and rheumatoid arthritis. These observations, together with experimental studies, suggest a critical role for vitamin D in the modulation of immune function. This leads to the hypothesis of a disease-specific alteration of vitamin D metabolism and reinforces the role of vitamin D in maintaining a healthy immune system. Two key observations validate this important non-classical action of vitamin D: first, vitamin D receptor (VDR) is expressed by the majority of immune cells, including B and T lymphocytes, monocytes, macrophages, and dendritic cells; second, there is an active vitamin D metabolism by immune cells that is able to locally convert 25(OH)D₃ into 1,25(OH)₂D₃, its active form. Vitamin D and VDR signaling together have a suppressive role on autoimmunity and an anti-inflammatory effect, promoting dendritic cell and regulatory T-cell differentiation and reducing T helper Th 17 cell response and inflammatory cytokines secretion. This review summarizes experimental data and clinical observations on the potential immunomodulating properties of vitamin D.
Keywords
Adaptive Immunity/drug effects, Animals, Anti-Infective Agents/blood, Anti-Infective Agents/pharmacology, Anti-Inflammatory Agents/blood, Anti-Inflammatory Agents/pharmacology, Autoimmune Diseases/blood, Autoimmune Diseases/prevention & control, Disease Models, Animal, Host-Pathogen Interactions/drug effects, Humans, Immunologic Factors/blood, Immunologic Factors/pharmacology, Microbiota/drug effects, Nutritional Status, Vitamin D/blood, Vitamin D/pharmacology, Vitamin D Deficiency/blood, Vitamin D Deficiency/drug therapy, T cells, autoimmune diseases, gut microbiota, immune system, vitamin D
Pubmed
Web of science
Open Access
Yes
Create date
13/01/2020 15:23
Last modification date
14/01/2020 6:26
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