Making sense of the natural antisense transcript puzzle.

Details

Serval ID
serval:BIB_4A35DD9172E9
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Making sense of the natural antisense transcript puzzle.
Journal
Trends in plant science
Author(s)
Reis R.S., Poirier Y.
ISSN
1878-4372 (Electronic)
ISSN-L
1360-1385
Publication state
Published
Issued date
11/2021
Peer-reviewed
Oui
Volume
26
Number
11
Pages
1104-1115
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
In plants, thousands of genes are associated with antisense transcription, which often produces noncoding RNAs. Although widespread, sense-antisense pairs have been implicated in a limited variety of functions in plants and are often thought to form extensive dsRNA stretches triggering gene silencing. In this opinion, we show that evidence does not support gene silencing as a major role for antisense transcription. In fact, it is more likely that antisense transcripts play diverse functions in gene regulation. We propose a general framework for the initial functional dissection of antisense transcripts, suggesting testable hypotheses relying on an experiment-based decision tree. By moving beyond the gene silencing paradigm, we argue that a broad and diverse role for natural antisense transcription will emerge.
Keywords
Gene Expression Regulation, RNA, Antisense/genetics, RNA, Untranslated, Transcription, Genetic, RNA–RNA interaction, natural antisense transcript, noncoding RNA, silencing
Pubmed
Web of science
Create date
02/08/2021 14:58
Last modification date
03/03/2022 7:34
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