Indocyanine green lymphography as novel tool to assess lymphatics in patients with lipedema.

Details

Serval ID
serval:BIB_4A2DCF1745FE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Indocyanine green lymphography as novel tool to assess lymphatics in patients with lipedema.
Journal
Microvascular research
Author(s)
Buso G., Favre L., Maufus M., Honorati M., Lessert C., Depairon M., Raffoul W., Tomson D., Mazzolai L.
ISSN
1095-9319 (Electronic)
ISSN-L
0026-2862
Publication state
Published
Issued date
03/2022
Peer-reviewed
Oui
Volume
140
Pages
104298
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Lipedema is a chronic and progressive disease associated with lymphatic impairment at later stages. The aim of our study was to describe the functional status and anatomy of lower limb superficial lymphatic system using indocyanine green (ICG) lymphography in patients with lipedema.
Following ICG injection at the dorsum of the foot, distance (cm) covered by the dye at 10 (T10') and 25 min (T25') was measured and normalized for limb length. If the dye did not reach the groin within 25 min, patients were classified as "drainage-needing" group (DNG). Values of fat and lean distribution assessed by dual-energy X-ray absorptiometry were extracted, and correlation analysis was performed. Furthermore, anatomical patterns of superficial lymphatics were assessed.
Overall, 45 women were included, 25 (56%) of whom were classified as DNG. Symptoms duration was significantly associated with DNG status at multivariate analysis (odds ratio 1.07; 95% CI 1.01-1.14; p = 0.047). Moreover, Spearman's analysis showed a negative correlation between symptoms duration and T25' dye migration (r = -0.469; p = 0.037). Overall, no major anatomical lymphatic changes were found.
Present study suggests that lymphatic functioning in patients with lipedema correlates with symptoms duration. Further research on larger cohorts should verify our findings and clarify their potential therapeutic implications. Overall, ICG lymphography may be promising technique to assess both lymphatic anatomy and functioning in patients with lipedema.
Keywords
Absorptiometry, Photon, Adiposity, Adult, Early Diagnosis, Female, Fluorescent Dyes, Humans, Indocyanine Green, Lipedema/diagnostic imaging, Lipedema/physiopathology, Lower Extremity, Lymphatic Vessels/diagnostic imaging, Lymphatic Vessels/physiopathology, Lymphography/methods, Male, Optical Imaging, Predictive Value of Tests, Retrospective Studies, Body composition assessment, Indocyanine green lymphography, Lipedema, Lymphatic disease
Pubmed
Web of science
Create date
20/12/2021 14:14
Last modification date
09/04/2022 6:33
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