Dyskinesia-inducing lead contacts optimize outcome of subthalamic stimulation in Parkinson's disease

Details

Serval ID
serval:BIB_4A0795640D28
Type
Article: article from journal or magazin.
Collection
Publications
Title
Dyskinesia-inducing lead contacts optimize outcome of subthalamic stimulation in Parkinson's disease
Journal
Mov Disord
Author(s)
Bouthour W., Bereau M., Kibleur A., Zacharia A., Tomkova Chaoui E., Fleury V., Benis D., Momjian S., Bally J., Luscher C., Krack P., Burkhard P. R.
ISSN
1531-8257 (Electronic)
ISSN-L
0885-3185
Publication state
Published
Issued date
11/2019
Volume
34
Number
11
Pages
1728-1734
Language
english
Notes
Bouthour, Walid
Bereau, Matthieu
Kibleur, Astrid
Zacharia, Andre
Tomkova Chaoui, Emilie
Fleury, Vanessa
Benis, Damien
Momjian, Shahan
Bally, Julien
Luscher, Christian
Krack, Paul
Burkhard, Pierre R
eng
Mov Disord. 2019 Nov;34(11):1728-1734. doi: 10.1002/mds.27853. Epub 2019 Sep 30.
Abstract
BACKGROUND: Acute dyskinesias elicited by STN-DBS, here referred to as stimulation-induced dyskinesias, predict optimal clinical outcome in PD. However, it remains elusive whether stimulation-induced dyskinesias can guide DBS programming. OBJECTIVES: Here, we characterized stimulation-induced dyskinesias clinically and anatomically. We then tested whether dyskinesia-inducing contacts could be effectively programmed using independent current source technology. METHODS: We characterized stimulation-induced dyskinesias with directional and ring stimulation retrospectively in 20 patients. We then localized dyskinesia-inducing contacts by imaging coregistration and eventually programmed those contacts. RESULTS: We elicited dyskinesias in half of our patients. Dyskinesia-inducing contacts were mainly directional and were all located ventrally within the dorsolateral motor STN. When these dyskinesia-inducing contacts were programmed using independent current source technology, dyskinesia disappeared and robust antibradykinetic effects were obtained. CONCLUSION: We confirm that stimulation-induced dyskinesias are helpful clinical observations, which may guide programming of directional STN-DBS in PD. (c) 2019 International Parkinson and Movement Disorder Society.
Keywords
*Deep Brain Stimulation/methods, Dyskinesias/*complications/therapy, Female, Humans, Male, Parkinson Disease/*therapy, Retrospective Studies, Subthalamic Nucleus/*surgery, Treatment Outcome, *Parkinson's disease, *deep brain stimulation, *directional, *stimulation-induced dyskinesia, *subthalamic nucleus
Pubmed
Create date
21/05/2021 9:09
Last modification date
22/05/2021 5:34
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