Dyskinesia-inducing lead contacts optimize outcome of subthalamic stimulation in Parkinson's disease
Details
Serval ID
serval:BIB_4A0795640D28
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Dyskinesia-inducing lead contacts optimize outcome of subthalamic stimulation in Parkinson's disease
Journal
Mov Disord
ISSN
1531-8257 (Electronic)
ISSN-L
0885-3185
Publication state
Published
Issued date
11/2019
Volume
34
Number
11
Pages
1728-1734
Language
english
Notes
Bouthour, Walid
Bereau, Matthieu
Kibleur, Astrid
Zacharia, Andre
Tomkova Chaoui, Emilie
Fleury, Vanessa
Benis, Damien
Momjian, Shahan
Bally, Julien
Luscher, Christian
Krack, Paul
Burkhard, Pierre R
eng
Mov Disord. 2019 Nov;34(11):1728-1734. doi: 10.1002/mds.27853. Epub 2019 Sep 30.
Bereau, Matthieu
Kibleur, Astrid
Zacharia, Andre
Tomkova Chaoui, Emilie
Fleury, Vanessa
Benis, Damien
Momjian, Shahan
Bally, Julien
Luscher, Christian
Krack, Paul
Burkhard, Pierre R
eng
Mov Disord. 2019 Nov;34(11):1728-1734. doi: 10.1002/mds.27853. Epub 2019 Sep 30.
Abstract
BACKGROUND: Acute dyskinesias elicited by STN-DBS, here referred to as stimulation-induced dyskinesias, predict optimal clinical outcome in PD. However, it remains elusive whether stimulation-induced dyskinesias can guide DBS programming. OBJECTIVES: Here, we characterized stimulation-induced dyskinesias clinically and anatomically. We then tested whether dyskinesia-inducing contacts could be effectively programmed using independent current source technology. METHODS: We characterized stimulation-induced dyskinesias with directional and ring stimulation retrospectively in 20 patients. We then localized dyskinesia-inducing contacts by imaging coregistration and eventually programmed those contacts. RESULTS: We elicited dyskinesias in half of our patients. Dyskinesia-inducing contacts were mainly directional and were all located ventrally within the dorsolateral motor STN. When these dyskinesia-inducing contacts were programmed using independent current source technology, dyskinesia disappeared and robust antibradykinetic effects were obtained. CONCLUSION: We confirm that stimulation-induced dyskinesias are helpful clinical observations, which may guide programming of directional STN-DBS in PD. (c) 2019 International Parkinson and Movement Disorder Society.
Keywords
*Deep Brain Stimulation/methods, Dyskinesias/*complications/therapy, Female, Humans, Male, Parkinson Disease/*therapy, Retrospective Studies, Subthalamic Nucleus/*surgery, Treatment Outcome, *Parkinson's disease, *deep brain stimulation, *directional, *stimulation-induced dyskinesia, *subthalamic nucleus
Pubmed
Create date
21/05/2021 9:09
Last modification date
22/05/2021 5:34