Specialized structure and function of the apical extracellular matrix at sense organs.
Details
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State: Public
Version: Final published version
License: CC BY-NC 4.0
State: Public
Version: Final published version
License: CC BY-NC 4.0
Serval ID
serval:BIB_49F9F6D58365
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Specialized structure and function of the apical extracellular matrix at sense organs.
Journal
Cells & development
ISSN
2667-2901 (Electronic)
ISSN-L
2667-2901
Publication state
Published
Issued date
09/2024
Peer-reviewed
Oui
Volume
179
Pages
203942
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Abstract
Apical extracellular matrix (aECM) covers every surface of the body and exhibits tissue-specific structures that carry out specialized functions. This is particularly striking at sense organs, where aECM forms the interface between sensory neurons and the environment, and thus plays critical roles in how sensory stimuli are received. Here, we review the extraordinary adaptations of aECM across sense organs and discuss how differences in protein composition and matrix structure assist in sensing mechanical forces (tactile hairs, campaniform sensilla, and the tectorial membrane of the cochlea); tastes and smells (uniporous gustatory sensilla and multiporous olfactory sensilla in insects, and salivary and olfactory mucus in vertebrates); and light (cuticle-derived lenses in arthropods and mollusks). We summarize the power of using C. elegans, in which defined sense organs associate with distinct aECM, as a model for understanding the tissue-specific structural and functional specializations of aECM. Finally, we synthesize results from recent studies in C. elegans and Drosophila into a conceptual framework for aECM patterning, including mechanisms that involve transient cellular or matrix scaffolds, mechanical pulling or pushing forces, and localized secretion or endocytosis.
Keywords
Animals, Extracellular Matrix/metabolism, Sense Organs/metabolism, Caenorhabditis elegans/metabolism, Humans, Sensory Receptor Cells/metabolism, Apical extracellular matrix, C. elegans, Ciliated sensory neurons, Drosophila, Sense organs, aECM
Pubmed
Web of science
Open Access
Yes
Create date
05/08/2024 17:07
Last modification date
10/09/2024 7:22