Relationships of plasminogen activator inhibitor activity and lipoprotein(a) with insulin, testosterone, 17 beta-estradiol, and testosterone binding globulin in myocardial infarction patients and healthy controls

Details

Serval ID
serval:BIB_49DB119DB11A
Type
Article: article from journal or magazin.
Collection
Publications
Title
Relationships of plasminogen activator inhibitor activity and lipoprotein(a) with insulin, testosterone, 17 beta-estradiol, and testosterone binding globulin in myocardial infarction patients and healthy controls
Journal
Journal of Clinical Endocrinology and Metabolism
Author(s)
Marques-Vidal P., Sie P., Cambou J.P., Chap H., Perret B.
ISSN
0021-972X (Print)
ISSN-L
0021-972X
Publication state
Published
Issued date
1995
Volume
80
Number
6
Pages
1794-1798
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The relationships between plasminogen activator inhibitor (PAi) activity and lipoprotein(a) [Lp(a)] and insulin, testosterone, 17 beta-estradiol, and testosterone binding globulin (TEBG) were assessed in 42 myocardial infarction male patients and 74 healthy controls. Patients had higher levels of insulin than did controls (87 +/- 30 vs. 75 +/- 28 pmol/L, respectively; P < 0.04), and no differences were found in levels of PAi activity, testosterone, 17 beta-estradiol, and TEBG. Lp(a) levels greater than 0.3 g/L were more frequent in patients than in controls (P < 0.002). In all subjects, PAi activity levels were significantly and positively correlated with body mass index (r = 0.20, P < 0.05), triglycerides (r = 0.38, P < 0.0001), and insulin (r = 0.27, P < 0.005) and were negatively correlated with testosterone (r = -0.28, P < 0.005) and TEBG (r = -0.42, P < 0.001). Stepwise multiple regression analysis showed triglyceride, insulin, and TEBG levels to be significantly related to PAi activity. No significant correlations were found between Lp(a) levels and all hormonal variables studied and between Lp(a) and PAi activity (r = -0.06, P < 0.58). These results suggest that TEBG is significantly and independently related to PAi levels.
Keywords
Estradiol/blood, Insulin/blood, Lipids/blood, Lipoprotein(a)/blood, Myocardial Infarction/blood, Plasminogen Inactivators/blood, Sex Hormone-Binding Globulin/metabolism, Testosterone/blood, Triglycerides/blood
Pubmed
Web of science
Create date
01/12/2016 15:02
Last modification date
20/08/2019 13:57
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