Normal weight obesity: relationship with lipids, glycaemic status, liver enzymes and inflammation.

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State: Public
Version: author
Serval ID
serval:BIB_49CC81EA7BA2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Normal weight obesity: relationship with lipids, glycaemic status, liver enzymes and inflammation.
Journal
Nutrition, metabolism, and cardiovascular diseases
Author(s)
Marques-Vidal P., Pécoud A., Hayoz D., Paccaud F., Mooser V., Waeber G., Vollenweider P.
ISSN
1590-3729 (Electronic)
ISSN-L
0939-4753
Publication state
Published
Issued date
11/2010
Peer-reviewed
Oui
Volume
20
Number
9
Pages
669-675
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Normal weight obesity (NWO) is defined as an excessive body fat associated with a normal body mass index (BMI) and has been associated with early inflammation, but its relationship with cardiovascular risk factors await investigation.
Cross-sectional study including 3213 women and 2912 men aged 35-75 years to assess the clinical characteristics of NWO in Lausanne, Switzerland. Body fat was assessed by bioimpedance. NWO was defined as a BMI<25 kg/m(2) and a % body fat ≥66(th) gender-specific percentiles. The prevalence of NWO was 5.4% in women and less than 3% in men, so the analysis was restricted to women. NWO women had a higher % of body fat than overweight women. After adjusting for age, smoking, educational level, physical activity and alcohol consumption, NWO women had higher blood pressure and lipid levels and a higher prevalence of dyslipidaemia (odds-ratio=1.90 [1.34-2.68]) and fasting hyperglycaemia (odds-ratio=1.63 [1.10-2.42]) than lean women, whereas no differences were found between NWO and overweight women. Conversely, no differences were found between NWO and lean women regarding levels of CRP, adiponectin and liver markers (alanine aminotransferase, aspartate aminotransferase and gamma glutamyl transferase). Using other definitions of NWO led to similar conclusions, albeit some differences were no longer significant.
NWO is almost nonexistent in men. Women with NWO present with higher cardiovascular risk factors than lean women, while no differences were found for liver or inflammatory markers. Specific screening of NWO might be necessary in order to implement cardiovascular prevention.

Keywords
Adiponectin/blood, Adult, Aged, Alanine Transaminase/blood, Aspartate Aminotransferases/blood, Blood Glucose/analysis, Body Fat Distribution, Body Weight, C-Reactive Protein/analysis, Cardiovascular Diseases, Female, Humans, Inflammation, Lipids/blood, Liver/enzymology, Male, Middle Aged, Obesity/blood, Risk Factors, Sex Factors, gamma-Glutamyltransferase/blood
Pubmed
Web of science
Create date
25/01/2010 15:38
Last modification date
20/08/2019 13:57
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