Comparaison du propacetamol et de la morphine dans l'analgesie postoperatoire. [Comparison of propacetamol and morphine in postoperative analgesia]

Details

Serval ID
serval:BIB_496F878E7432
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Comparaison du propacetamol et de la morphine dans l'analgesie postoperatoire. [Comparison of propacetamol and morphine in postoperative analgesia]
Journal
Schweizerische Medizinische Wochenschrift
Author(s)
Vuilleumier  P. A., Buclin  T., Biollaz  J.
ISSN
0036-7672 (Print)
Publication state
Published
Issued date
02/1998
Volume
128
Number
7
Pages
259-63
Notes
Clinical Trial
Comparative Study
English Abstract
Journal Article
Randomized Controlled Trial --- Old month value: Feb 14
Abstract
To compare the analgesic efficacy and tolerance of propacetamol and morphine, 80 patients in good clinical condition were included in a prospective, parallel, randomized double blind trial after elective surgery expected to elicit light to moderate postoperative pain. At the end of general anesthesia, 40 patients received 30 mg/kg propacetamol and 40 0.2 mg/kg morphine, as a 15-min intravenous infusion. The groups were similar for age, weight and duration of anesthesia. Supplemental analgesia had to be given in 7 cases from the propacetamol group vs. 2 cases from the morphine group. The postoperative pain, evaluated 7 times during 4 h from the end of infusion with a visual analog scale, revealed a modest advantage for morphine at 0.5 and 4 h (p = 0.05). The respiratory rate was slightly lower after morphine (p = 0.02). No significant differences were observed in blood oxygen saturation, blood pressure, heart rate, body temperature and vigilance evaluated by the trailmaking test. Nausea was present in 4 cases under propacetamol and 3 under morphine, and pruritus in 2 and 7 cases, respectively. In conclusion, propacetamol may represent an alternative to morphine for pain prevention after mildly to moderately painful surgery in situations where the use of opioids is unsuitable.
Keywords
Acetaminophen/adverse effects/*analogs & derivatives/therapeutic use Adult Analgesics/adverse effects/*therapeutic use Analgesics, Opioid/adverse effects/*therapeutic use Double-Blind Method Female Humans Infusions, Intravenous Male Middle Aged Morphine/adverse effects/*therapeutic use Pain Measurement Pain, Postoperative/*drug therapy Prodrugs/adverse effects/*therapeutic use Prospective Studies Treatment Outcome
Pubmed
Web of science
Create date
25/01/2008 11:41
Last modification date
20/08/2019 14:56
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