Biomarkers of cerebral damage in fatal hypothermia

Details

Ressource 1Download: Mémoire no 5576 M. Morleo.pdf (221.45 [Ko])
State: Public
Version: After imprimatur
License: Not specified
Serval ID
serval:BIB_492DA6AF310B
Type
A Master's thesis.
Publication sub-type
Master (thesis) (master)
Collection
Publications
Institution
Title
Biomarkers of cerebral damage in fatal hypothermia
Author(s)
MORLEO B.
Director(s)
PALMIERE C.
Institution details
Université de Lausanne, Faculté de biologie et médecine
Publication state
Accepted
Issued date
2018
Language
english
Number of pages
9
Abstract
The identification of hypothermia as the cause of death remains challenging in forensic pathology because of unspecific radiological, morphological, and biochemical results. Hyperaemia, oedema, and petechial haemorrhages within the cerebral parenchyma were described in cases of death by hypothermia. On the other hand, the effect of low temperatures in the brain has been speculated to cause local injuries on a cellular level with potential occurrences of necrosis, and inflammation. In the study herein described, endocan, alkaline phosphatase, neuronal specific enolase, S100 protein subunit B, glial fibrillary acidic protein, and C-reactive protein were measured in postmortem serum from femoral blood and cerebrospinal fluid in a series of hypothermia fatalities and control cases. The combination of data collected failed to identify a specific biochemical profile for death by hypothermia in postmortem serum and/or the cerebrospinal fluid, thus suggesting that an alternative panel of brain damage biomarkers indicative of diffuse hypoxic brain injury need to be defined in hypothermia fatalities.
Keywords
Hypothermia, Postmortem biochemistry, Biomarkers, Autopsy
Create date
03/09/2019 9:47
Last modification date
08/09/2020 7:08
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