BAFF mediates survival of peripheral immature B lymphocytes.

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Serval ID
serval:BIB_48F8BF4595A9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
BAFF mediates survival of peripheral immature B lymphocytes.
Journal
Journal of Experimental Medicine
Author(s)
Batten M., Groom J., Cachero T.G., Qian F., Schneider P., Tschopp J., Browning J.L., Mackay F.
ISSN
0022-1007 (Print)
ISSN-L
0022-1007
Publication state
Published
Issued date
2000
Volume
192
Number
10
Pages
1453-1466
Language
english
Abstract
B cell maturation is a very selective process that requires finely tuned differentiation and survival signals. B cell activation factor from the TNF family (BAFF) is a TNF family member that binds to B cells and potentiates B cell receptor (BCR)-mediated proliferation. A role for BAFF in B cell survival was suggested by the observation of reduced peripheral B cell numbers in mice treated with reagents blocking BAFF, and high Bcl-2 levels detected in B cells from BAFF transgenic (Tg) mice. We tested in vitro the survival effect of BAFF on lymphocytes derived from primary and secondary lymphoid organs. BAFF induced survival of a subset of splenic immature B cells, referred to as transitional type 2 (T2) B cells. BAFF treatment allowed T2 B cells to survive and differentiate into mature B cells in response to signals through the BCR. The T2 and the marginal zone (MZ) B cell compartments were particularly enlarged in BAFF Tg mice. Immature transitional B cells are targets for negative selection, a feature thought to promote self-tolerance. These findings support a model in which excessive BAFF-mediated survival of peripheral immature B cells contributes to the emergence and maturation of autoreactive B cells, skewed towards the MZ compartment. This work provides new clues on mechanisms regulating B cell maturation and tolerance.
Keywords
Animals, Autoimmunity, B-Cell Activating Factor, B-Lymphocyte Subsets/cytology, B-Lymphocyte Subsets/immunology, Cell Differentiation, Cell Survival, Cells, Cultured, Hematopoietic Stem Cells/cytology, Hematopoietic Stem Cells/immunology, Membrane Proteins/metabolism, Mice, Models, Immunological, Spleen/cytology, Spleen/immunology, Tumor Necrosis Factor-alpha/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 15:18
Last modification date
20/08/2019 13:56
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