Vaccine effectiveness in older individuals: what has been learned from the influenza-vaccine experience.

Details

Serval ID
serval:BIB_48C7E5885316
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Vaccine effectiveness in older individuals: what has been learned from the influenza-vaccine experience.
Journal
Ageing Research Reviews
Author(s)
Lang P.O., Govind S., Mitchell W.A., Siegrist C.A., Aspinall R.
ISSN
1872-9649 (Electronic)
ISSN-L
1568-1637
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
10
Number
3
Pages
389-395
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Vaccination policies in most high-income countries attempt to reduce the adverse impact of influenza targeting people aged at least 60 years. However, while it is widely believed that the current immunization strategy saves many lives, influenza infection still remains a severe burden in aged individuals leading to a wide debate on the exact magnitude of the benefit of vaccination in this population. The first aim of the present review is to examine how effective current influenza-vaccine strategies are in aged adults, by analysing which are the most important factors modulating the interpretation of study results in this population. Furthermore, consideration will be given to how immune factors influence the measurement of vaccine efficacy/effectiveness, where advancing age leads to deleterious changes in the adaptive immune system, resulting in less than optimal responses to infectious agents and vaccination. Finally this review concludes with possible strategies to improve the ability of the senescent immune system to respond to vaccination.
Keywords
Adaptive Immunity/physiology, Aged, Aged, 80 and over, Aging/immunology, Humans, Influenza Vaccines/therapeutic use, Influenza, Human/immunology, Influenza, Human/prevention & control, Treatment Outcome
Pubmed
Web of science
Create date
15/04/2015 9:33
Last modification date
20/08/2019 13:55
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