Angiotensinergic Innervation of the Human Right Atrium: Implications for Cardiac Reflexes.

Details

Ressource 1Download: 28985343_BIB_48B4C8F9668B.pdf (26235.57 [Ko])
State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_48B4C8F9668B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Angiotensinergic Innervation of the Human Right Atrium: Implications for Cardiac Reflexes.
Journal
American journal of hypertension
Author(s)
Bohlender J.M., Nussberger J., Tevaearai H., Imboden H.
ISSN
1941-7225 (Electronic)
ISSN-L
0895-7061
Publication state
Published
Issued date
12/01/2018
Peer-reviewed
Oui
Volume
31
Number
2
Pages
188-196
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The right atrium is densely innervated and provides sensory input to important cardiocirculatory reflexes controlling cardiac output and blood pressure. Its angiotensin (Ang) II-expressing innervation may release Ang II as a neuropeptide cotransmitter to modulate reflexes but has not yet been characterized.
Intraoperative surgical biopsies from human right atria (n = 7) were immunocytologically stained for Ang II, tyrosine hydroxylase (TH), and synaptophysin (SYN). Tissue angiotensins were extracted and quantified by radioimmunoassay.
Angiotensinergic fibers were frequent in epicardial nerves and around vessels with variable TH co-localization (none to >50%/bundle). Fibers were also widely distributed between cardiomyocytes and in the endocardium where they were typically nonvaricose, TH/SYN-negative and usually accompanied by varicose catecholaminergic fibers. In the endocardium, some showed large varicosities and were partially TH or SYN-positive. A few endocardial regions showed scattered nonvaricose Ang fibers ending directly between endothelial cells. Occasional clusters of thin varicose terminals co-localizing SYN or TH were located underneath, or protruded into, the endothelium. Endocardial density of Ang and TH-positive fibers was 30-300 vs. 200-450/mm2. Atrial Ang II, III, and I concentrations were 67, 16, and 5 fmol/g (median) while Ang IV and V were mostly undetectable.
The human right atrium harbors an abundant angiotensinergic innervation and a novel potential source of atrial Ang II. Most peripheral fibers were noncatecholaminergic afferents or preterminal vagal efferents and a minority was presumably sympathetic. Neuronal Ang II release from these fibers may modulate cardiac and circulatory reflexes independently from plasma and tissue Ang II sources.
Keywords
Aged, Angiotensin I/analysis, Angiotensin II/analogs & derivatives, Angiotensin II/analysis, Angiotensin III/analysis, Angiotensins/analysis, Autonomic Nervous System/chemistry, Heart Atria/innervation, Humans, Male, Middle Aged, Nerve Fibers/chemistry, Peptide Fragments/analysis, Reflex, Synaptophysin/analysis, Tyrosine 3-Monooxygenase/analysis, angiotensin, blood pressure, cardiomyocyte, heart atria, human, hypertension, innervation, sympathetic
Pubmed
Web of science
Open Access
Yes
Create date
19/10/2017 17:32
Last modification date
04/10/2019 6:09
Usage data